TY  - CONF
AU  - Engelhardt, Jakob
TI  - W01-5: Influence of auxiliary subunits on AMPAR function in hippo-campus and thalamus
JO  - Acta physiologica
VL  - 216
IS  - S707
SN  - 0001-6772
M1  - DZNE-2020-00907
SP  - Workshop 1
PY  - 2016
AB  - Auxiliary subunits modulate function, surface trafficking and subcellular localization of AMPA receptors. I will present data from our laboratory on how we investigate the func-tion of auxiliary subunits of the CKAMP and TARP families in heterologous expression systems, acute brain slices and in vivo. Number and properties of synaptic and extrasynaptic AMPA receptors in dentate gyrus granule cells and lateral geniculate relay neurons are strongly influenced by the inter-action with CKAMP44 and TARP y-8. Moreover, these two auxiliary subunits affect synaptic short-term and long-term plasticity. Finally, tetrode recordings from non-anaesthetized mice revealed that auxiliary proteins change the activity of neurons by modulating the integration of excitatory inputs.
T2  - 95th Annual Meeting of the German Physiological Society
CY  - 3 Mar 2016 - 5 Mar 2016, Lübeck (Germany)
Y2  - 3 Mar 2016 - 5 Mar 2016
M2  - Lübeck, Germany
LB  - PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
UR  - https://pub.dzne.de/record/145574
ER  -