%0 Conference Paper
%A Kaczmarczyk, Lech
%A Jackson, Walker Scot
%T Caribou Prnp polymorphism distribution in Canada and its impact on CWD pathogenesis
%J Prion
%V 13
%@ 1933-6896
%M DZNE-2020-00908
%P 28 - 29
%D 2019
%X Wild reindeer in Norway were recently diagnosed withchronic wasting disease (CWD) [1]. Prions from CWD-infected deer were also transmissible to other reindeer inexperimental settings [2,3]. Although CWD has not yetbeen reported in wild reindeer (caribou) in Canada, thesestudies show that they are at risk of infection. The wild-typereindeer, homozygous for serine at prion protein (PrP)residue 138 (138SS), developed clinical disease upon oralinoculation. Animals carrying at least one asparagine allele(138SN, 138NN) accumulated prions only in the periphery.However, both genotypes were susceptible to intracerebralprion inoculation [2,3]. Fallow deer are wild-type 138NNand are resistant to peripheral but not intracerebral prioninfection [4]. Thus, we hypothesize that the138N allele,present in caribou herds in Alberta [5], alters CWD patho-genesis by limiting prion transport from the periphery tothe CNS. Our aim is to elucidate the mechanisms involvedin this process.We extracted DNA from ±800 caribou, sequenced thePrnpopen reading frame and determined the 138N alleleprevalence in Canadian caribou populations. Resultsshow that the 138N allele was highly prevalent in theChinchaga woodland caribou population in BC (64
%B PRION 2019
%C 21 May 2019 - 24 May 2019, Edmonton (Canada)
Y2 21 May 2019 - 24 May 2019
M2 Edmonton, Canada
%F PUB:(DE-HGF)1 ; PUB:(DE-HGF)16
%9 AbstractJournal Article
%U https://pub.dzne.de/record/145575