000145589 001__ 145589
000145589 005__ 20200925154156.0
000145589 037__ $$aDZNE-2020-00922
000145589 041__ $$aEnglish
000145589 1001_ $$0P:(DE-2719)2812134$$aReuter, Martin$$b0$$udzne
000145589 1112_ $$aMICCAI 2017$$cQuebec City$$d2017-09-10 - 2017-09-14$$wCanada
000145589 245__ $$aLatent processes governing neuroanatomical change in aging and dementia
000145589 260__ $$c2017
000145589 3367_ $$033$$2EndNote$$aConference Paper
000145589 3367_ $$2DataCite$$aOther
000145589 3367_ $$2BibTeX$$aINPROCEEDINGS
000145589 3367_ $$2DRIVER$$aconferenceObject
000145589 3367_ $$2ORCID$$aLECTURE_SPEECH
000145589 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1597323561_1959$$xOther
000145589 520__ $$aClinically normal aging and pathological processes cause structural changes in the brain. These changes likely occur in overlapping regions that accommodate neural systems with high susceptibility to deleterious factors. Due to the overlap, the separation between aging and pathological processes is challenging when analyzing brain structures independently. We propose to identify multivariate latent processes that govern cross-sectional and longitudinal neuroanatomical changes across the brain in aging and dementia. A discriminative representation of neuroanatomy is obtained from spectral shape descriptors in the BrainPrint. We identify latent factors by maximizing the covariance between morphological change and response variables of age and a proxy for dementia. Our results reveal cross-sectional and longitudinal patterns of change in neuroanatomy that distinguishes aging processes from disease processes. Finally, latent processes do not only yield a parsimonious model but also a significantly improved prediction accuracy.
000145589 536__ $$0G:(DE-HGF)POF3-345$$a345 - Population Studies and Genetics (POF3-345)$$cPOF3-345$$fPOF III$$x0
000145589 8564_ $$uhttps://link.springer.com/chapter/10.1007/978-3-319-66179-7_4
000145589 909CO $$ooai:pub.dzne.de:145589$$pVDB
000145589 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812134$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000145589 9131_ $$0G:(DE-HGF)POF3-345$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vPopulation Studies and Genetics$$x0
000145589 9141_ $$y2017
000145589 9201_ $$0I:(DE-2719)1040310$$kAG Reuter$$lImage Analysis$$x0
000145589 980__ $$aconf
000145589 980__ $$aVDB
000145589 980__ $$aI:(DE-2719)1040310
000145589 980__ $$aUNRESTRICTED