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@INPROCEEDINGS{Reuter:145589,
      author       = {Reuter, Martin},
      title        = {{L}atent processes governing neuroanatomical change in
                      aging and dementia},
      reportid     = {DZNE-2020-00922},
      year         = {2017},
      abstract     = {Clinically normal aging and pathological processes cause
                      structural changes in the brain. These changes likely occur
                      in overlapping regions that accommodate neural systems with
                      high susceptibility to deleterious factors. Due to the
                      overlap, the separation between aging and pathological
                      processes is challenging when analyzing brain structures
                      independently. We propose to identify multivariate latent
                      processes that govern cross-sectional and longitudinal
                      neuroanatomical changes across the brain in aging and
                      dementia. A discriminative representation of neuroanatomy is
                      obtained from spectral shape descriptors in the BrainPrint.
                      We identify latent factors by maximizing the covariance
                      between morphological change and response variables of age
                      and a proxy for dementia. Our results reveal cross-sectional
                      and longitudinal patterns of change in neuroanatomy that
                      distinguishes aging processes from disease processes.
                      Finally, latent processes do not only yield a parsimonious
                      model but also a significantly improved prediction
                      accuracy.},
      month         = {Sep},
      date          = {2017-09-10},
      organization  = {MICCAI 2017, Quebec City (Canada), 10
                       Sep 2017 - 14 Sep 2017},
      subtyp        = {Other},
      cin          = {AG Reuter},
      cid          = {I:(DE-2719)1040310},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://pub.dzne.de/record/145589},
}