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000151070 1001_ $$0P:(DE-HGF)0$$aLlorens, Franc$$b0$$eCorresponding author
000151070 245__ $$aDiagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
000151070 260__ $$aBasel$$bMDPI$$c2020
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000151070 500__ $$ahttps://www.mdpi.com/2218-273X/10/2/290
000151070 520__ $$aHuman prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt–Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD samples from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases.
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000151070 542__ $$2Crossref$$i2020-02-12$$uhttps://creativecommons.org/licenses/by/4.0/
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000151070 650_2 $$2MeSH$$aAdult
000151070 650_2 $$2MeSH$$aAged
000151070 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000151070 650_2 $$2MeSH$$aCorneal Transplantation: adverse effects
000151070 650_2 $$2MeSH$$aCreutzfeldt-Jakob Syndrome: cerebrospinal fluid
000151070 650_2 $$2MeSH$$aCreutzfeldt-Jakob Syndrome: diagnostic imaging
000151070 650_2 $$2MeSH$$aCreutzfeldt-Jakob Syndrome: epidemiology
000151070 650_2 $$2MeSH$$aDura Mater: transplantation
000151070 650_2 $$2MeSH$$aElectroencephalography
000151070 650_2 $$2MeSH$$aEncephalopathy, Bovine Spongiform: cerebrospinal fluid
000151070 650_2 $$2MeSH$$aEncephalopathy, Bovine Spongiform: diagnostic imaging
000151070 650_2 $$2MeSH$$aEncephalopathy, Bovine Spongiform: epidemiology
000151070 650_2 $$2MeSH$$aFemale
000151070 650_2 $$2MeSH$$aHomozygote
000151070 650_2 $$2MeSH$$aHuman Growth Hormone: adverse effects
000151070 650_2 $$2MeSH$$aHumans
000151070 650_2 $$2MeSH$$aIatrogenic Disease
000151070 650_2 $$2MeSH$$aKaplan-Meier Estimate
000151070 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000151070 650_2 $$2MeSH$$aMale
000151070 650_2 $$2MeSH$$aMethionine: genetics
000151070 650_2 $$2MeSH$$aMiddle Aged
000151070 650_2 $$2MeSH$$aNeuroimaging
000151070 650_2 $$2MeSH$$aPhenotype
000151070 650_2 $$2MeSH$$aPolymorphism, Genetic
000151070 650_2 $$2MeSH$$aPrion Diseases: cerebrospinal fluid
000151070 650_2 $$2MeSH$$aPrion Diseases: diagnostic imaging
000151070 650_2 $$2MeSH$$aPrion Proteins: metabolism
000151070 650_2 $$2MeSH$$aRegistries
000151070 650_2 $$2MeSH$$aReproducibility of Results
000151070 650_2 $$2MeSH$$aSex Factors
000151070 650_2 $$2MeSH$$aTime Factors
000151070 7001_ $$0P:(DE-HGF)0$$aVillar-Piqué, Anna$$b1$$eCorresponding author
000151070 7001_ $$0P:(DE-HGF)0$$aHermann, Peter$$b2
000151070 7001_ $$0P:(DE-2719)9000287$$aSchmitz, Matthias$$b3
000151070 7001_ $$aCalero, Olga$$b4
000151070 7001_ $$00000-0001-8282-9151$$aStehmann, Christiane$$b5
000151070 7001_ $$aSarros, Shannon$$b6
000151070 7001_ $$00000-0002-2820-9880$$aModa, Fabio$$b7
000151070 7001_ $$00000-0001-9888-8754$$aFerrer, Isidre$$b8
000151070 7001_ $$00000-0001-7094-7767$$aPoleggi, Anna$$b9
000151070 7001_ $$00000-0002-7269-2486$$aPocchiari, Maurizio$$b10
000151070 7001_ $$aCatania, Marcella$$b11
000151070 7001_ $$aKlotz, Sigrid$$b12
000151070 7001_ $$aO’Regan, Carl$$b13
000151070 7001_ $$aBrett, Francesca$$b14
000151070 7001_ $$aHeffernan, Josephine$$b15
000151070 7001_ $$aLadogana, Anna$$b16
000151070 7001_ $$aCollins, Steven J.$$b17
000151070 7001_ $$00000-0001-5366-3324$$aCalero, Miguel$$b18
000151070 7001_ $$aKovacs, Gabor G.$$b19
000151070 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b20$$eLast author
000151070 770__ $$aPrion Disease Biomarkers: Recent Advances
000151070 77318 $$2Crossref$$3journal-article$$a10.3390/biom10020290$$b : MDPI AG, 2020-02-12$$n2$$p290$$tBiomolecules$$v10$$x2218-273X$$y2020
000151070 773__ $$0PERI:(DE-600)2701262-1$$a10.3390/biom10020290$$gVol. 10, no. 2, p. 290 -$$n2$$p290$$tBiomolecules$$v10$$x2218-273X$$y2020
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