TY  - JOUR
AU  - Llorens, Franc
AU  - Villar-Piqué, Anna
AU  - Hermann, Peter
AU  - Schmitz, Matthias
AU  - Calero, Olga
AU  - Stehmann, Christiane
AU  - Sarros, Shannon
AU  - Moda, Fabio
AU  - Ferrer, Isidre
AU  - Poleggi, Anna
AU  - Pocchiari, Maurizio
AU  - Catania, Marcella
AU  - Klotz, Sigrid
AU  - O’Regan, Carl
AU  - Brett, Francesca
AU  - Heffernan, Josephine
AU  - Ladogana, Anna
AU  - Collins, Steven J.
AU  - Calero, Miguel
AU  - Kovacs, Gabor G.
AU  - Zerr, Inga
TI  - Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
JO  - Biomolecules
VL  - 10
IS  - 2
SN  - 2218-273X
CY  - Basel
PB  - MDPI
M1  - DZNE-2020-01055
SP  - 290
PY  - 2020
N1  - https://www.mdpi.com/2218-273X/10/2/290
AB  - Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt–Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD samples from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases.
KW  - Adult
KW  - Aged
KW  - Biomarkers: cerebrospinal fluid
KW  - Corneal Transplantation: adverse effects
KW  - Creutzfeldt-Jakob Syndrome: cerebrospinal fluid
KW  - Creutzfeldt-Jakob Syndrome: diagnostic imaging
KW  - Creutzfeldt-Jakob Syndrome: epidemiology
KW  - Dura Mater: transplantation
KW  - Electroencephalography
KW  - Encephalopathy, Bovine Spongiform: cerebrospinal fluid
KW  - Encephalopathy, Bovine Spongiform: diagnostic imaging
KW  - Encephalopathy, Bovine Spongiform: epidemiology
KW  - Female
KW  - Homozygote
KW  - Human Growth Hormone: adverse effects
KW  - Humans
KW  - Iatrogenic Disease
KW  - Kaplan-Meier Estimate
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Methionine: genetics
KW  - Middle Aged
KW  - Neuroimaging
KW  - Phenotype
KW  - Polymorphism, Genetic
KW  - Prion Diseases: cerebrospinal fluid
KW  - Prion Diseases: diagnostic imaging
KW  - Prion Proteins: metabolism
KW  - Registries
KW  - Reproducibility of Results
KW  - Sex Factors
KW  - Time Factors
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC7072321
C6  - pmid:32059611
DO  - DOI:10.3390/biom10020290
UR  - https://pub.dzne.de/record/151070
ER  -