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@ARTICLE{Llorens:151070,
      author       = {Llorens, Franc and Villar-Piqué, Anna and Hermann, Peter
                      and Schmitz, Matthias and Calero, Olga and Stehmann,
                      Christiane and Sarros, Shannon and Moda, Fabio and Ferrer,
                      Isidre and Poleggi, Anna and Pocchiari, Maurizio and
                      Catania, Marcella and Klotz, Sigrid and O’Regan, Carl and
                      Brett, Francesca and Heffernan, Josephine and Ladogana, Anna
                      and Collins, Steven J. and Calero, Miguel and Kovacs, Gabor
                      G. and Zerr, Inga},
      title        = {{D}iagnostic {A}ccuracy of {P}rion {D}isease {B}iomarkers
                      in {I}atrogenic {C}reutzfeldt-{J}akob {D}isease},
      journal      = {Biomolecules},
      volume       = {10},
      number       = {2},
      issn         = {2218-273X},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2020-01055},
      pages        = {290},
      year         = {2020},
      note         = {https://www.mdpi.com/2218-273X/10/2/290},
      abstract     = {Human prion diseases are classified into sporadic, genetic,
                      and acquired forms. Within this last group, iatrogenic
                      Creutzfeldt–Jakob disease (iCJD) is caused by
                      human-to-human transmission through surgical and medical
                      procedures. After reaching an incidence peak in the 1990s,
                      it is believed that the iCJD historical period is probably
                      coming to an end, thanks to lessons learnt from past
                      infection sources that promoted new prion prevention and
                      decontamination protocols. At this point, we sought to
                      characterise the biomarker profile of iCJD and compare it to
                      that of sporadic CJD (sCJD) for determining the value of
                      available diagnostic tools in promptly recognising iCJD
                      cases. To that end, we collected 23 iCJD samples from seven
                      national CJD surveillance centres and analysed the
                      electroencephalogram and neuroimaging data together with a
                      panel of seven CSF biomarkers: 14-3-3, total tau,
                      phosphorylated/total tau ratio, alpha-synuclein,
                      neurofilament light, YKL-40, and real-time quaking induced
                      conversion of prion protein. Using the cut-off values
                      established for sCJD, we found the sensitivities of these
                      biomarkers for iCJD to be similar to those described for
                      sCJD. Given the limited relevant information on this issue
                      to date, the present study validates the use of current sCJD
                      biomarkers for the diagnosis of future iCJD cases.},
      keywords     = {Adult / Aged / Biomarkers: cerebrospinal fluid / Corneal
                      Transplantation: adverse effects / Creutzfeldt-Jakob
                      Syndrome: cerebrospinal fluid / Creutzfeldt-Jakob Syndrome:
                      diagnostic imaging / Creutzfeldt-Jakob Syndrome:
                      epidemiology / Dura Mater: transplantation /
                      Electroencephalography / Encephalopathy, Bovine Spongiform:
                      cerebrospinal fluid / Encephalopathy, Bovine Spongiform:
                      diagnostic imaging / Encephalopathy, Bovine Spongiform:
                      epidemiology / Female / Homozygote / Human Growth Hormone:
                      adverse effects / Humans / Iatrogenic Disease / Kaplan-Meier
                      Estimate / Magnetic Resonance Imaging / Male / Methionine:
                      genetics / Middle Aged / Neuroimaging / Phenotype /
                      Polymorphism, Genetic / Prion Diseases: cerebrospinal fluid
                      / Prion Diseases: diagnostic imaging / Prion Proteins:
                      metabolism / Registries / Reproducibility of Results / Sex
                      Factors / Time Factors},
      cin          = {AG Zerr},
      ddc          = {570},
      cid          = {I:(DE-2719)1440011-1},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC7072321},
      pubmed       = {pmid:32059611},
      doi          = {10.3390/biom10020290},
      url          = {https://pub.dzne.de/record/151070},
}