TY  - JOUR
AU  - Özden, Cansu
AU  - Frings, Lars
AU  - Apostolova, Ivayla
AU  - Lange, Catharina
AU  - Klutmann, Susanne
AU  - Adam, Gerhard
AU  - Bannas, Peter
AU  - Meyer, Philipp T.
AU  - Grothe, Michel J.
AU  - Buchert, Ralph
TI  - FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum
JO  - Clinical nuclear medicine
VL  - 45
IS  - 4
SN  - 0363-9762
CY  - [S.l.]
PB  - Ovid
M1  - DZNE-2020-01079
SP  - 261-266
PY  - 2020
AB  - Purpose Cognitive decline in diseases of the Lewy body spectrum (LBS) is linked to dysfunction/degeneration of the basal forebrain (BF). Assessment of glucose metabolism in the BF by FDG PET is hampered by the small size of the BF and limited spatial resolution of conventional PET. This pilot study tested the feasibility of assessing BF glucose metabolism by high-resolution digital PET (dPET).Patients and Methods The retrospective study included 12 LBS patients (61–86 years, 5 demented). Whole-brain stereotactic normalization to anatomical standard space was followed by local stereotactic normalization of a 7 × 7 × 7-cm3 box around the BF to a custom-made 1 × 1 × 1-mm3 FDG dPET template. FDG uptake was scaled voxelwise to mean FDG uptake in the pons. Scaled FDG uptake in the BF was compared between demented and nondemented LBS patients and tested for correlation with cortical FDG uptake.Results Scaled FDG uptake in the BF was significantly lower in demented compared with nondemented patients (1.14 ± 0.09 vs 1.25 ± 0.06, P = 0.031). Brain-wide voxel-based testing for correlations with scaled FDG uptake in the BF revealed a large cluster comprising medial and ventrolateral frontal cortex, anterior cingulate cortex, insular cortex, and striatum as well as smaller clusters in motor cortex and occipital cortex (P < 0.001, uncorrected).Conclusions These results suggest that dementia-associated BF degeneration in LBS can be sensitively measured as reduced BF FDG uptake on dPET. More accurate delineation of the BF based on individual high-resolution MRI might be useful to make optimal use of improved spatial resolution of dPET and to correct for possible disease- and age-dependent partial volume effects.
LB  - PUB:(DE-HGF)16
C6  - pmid:32108697
DO  - DOI:10.1097/RLU.0000000000002960
UR  - https://pub.dzne.de/record/151491
ER  -