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@ARTICLE{zden:151491,
      author       = {Özden, Cansu and Frings, Lars and Apostolova, Ivayla and
                      Lange, Catharina and Klutmann, Susanne and Adam, Gerhard and
                      Bannas, Peter and Meyer, Philipp T. and Grothe, Michel J.
                      and Buchert, Ralph},
      title        = {{FDG} {U}ptake in the {B}asal {F}orebrain as {M}easured by
                      {D}igital {H}igh-{R}esolution {PET} {I}s a {P}romising
                      {M}arker of {B}asal {F}orebrain {D}egeneration in the {L}ewy
                      {B}ody {D}isease {S}pectrum},
      journal      = {Clinical nuclear medicine},
      volume       = {45},
      number       = {4},
      issn         = {0363-9762},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DZNE-2020-01079},
      pages        = {261-266},
      year         = {2020},
      abstract     = {Purpose Cognitive decline in diseases of the Lewy body
                      spectrum (LBS) is linked to dysfunction/degeneration of the
                      basal forebrain (BF). Assessment of glucose metabolism in
                      the BF by FDG PET is hampered by the small size of the BF
                      and limited spatial resolution of conventional PET. This
                      pilot study tested the feasibility of assessing BF glucose
                      metabolism by high-resolution digital PET (dPET).Patients
                      and Methods The retrospective study included 12 LBS patients
                      (61–86 years, 5 demented). Whole-brain stereotactic
                      normalization to anatomical standard space was followed by
                      local stereotactic normalization of a 7 × 7 × 7-cm3 box
                      around the BF to a custom-made 1 × 1 × 1-mm3 FDG dPET
                      template. FDG uptake was scaled voxelwise to mean FDG uptake
                      in the pons. Scaled FDG uptake in the BF was compared
                      between demented and nondemented LBS patients and tested for
                      correlation with cortical FDG uptake.Results Scaled FDG
                      uptake in the BF was significantly lower in demented
                      compared with nondemented patients (1.14 ± 0.09 vs 1.25 ±
                      0.06, P = 0.031). Brain-wide voxel-based testing for
                      correlations with scaled FDG uptake in the BF revealed a
                      large cluster comprising medial and ventrolateral frontal
                      cortex, anterior cingulate cortex, insular cortex, and
                      striatum as well as smaller clusters in motor cortex and
                      occipital cortex (P < 0.001, uncorrected).Conclusions These
                      results suggest that dementia-associated BF degeneration in
                      LBS can be sensitively measured as reduced BF FDG uptake on
                      dPET. More accurate delineation of the BF based on
                      individual high-resolution MRI might be useful to make
                      optimal use of improved spatial resolution of dPET and to
                      correct for possible disease- and age-dependent partial
                      volume effects.},
      cin          = {U T4 Researchers - Bonn / Clinical Dementia Research
                      Rostock /Greifswald ; AG Teipel},
      ddc          = {610},
      cid          = {I:(DE-2719)7000008 / I:(DE-2719)1510100},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32108697},
      doi          = {10.1097/RLU.0000000000002960},
      url          = {https://pub.dzne.de/record/151491},
}