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000151540 0247_ $$2pmid$$apmid:32307300
000151540 0247_ $$2doi$$a10.1016/j.jocn.2020.04.052
000151540 0247_ $$2ISSN$$a0967-5868
000151540 0247_ $$2ISSN$$a1532-2653
000151540 037__ $$aDZNE-2020-01124
000151540 041__ $$aEnglish
000151540 082__ $$a610
000151540 1001_ $$aSchlapakow, Elena$$b0
000151540 245__ $$aMultiple system atrophy mimicry in MRI: Watch out for paraneoplastic rhombencephalitis
000151540 260__ $$aBurlington, Mass.$$bHarcourt$$c2020
000151540 264_1 $$2Crossref$$3print$$bElsevier BV$$c2020-06-01
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000151540 520__ $$aThe hot cross bun (HCB) sign describes cruciform-shaped T2-weighted hyperintensities of pontocerebellar fibers within the pons and is a typical, but not specific imaging hallmark of the cerebellar variant of multiple system atrophy (MSA-C). We report a case of a 51-year-old woman who was first diagnosed with MSA-C based on progressive cerebellar ataxia, the HCB sign and T2-weighted hyperintensities in middle cerebellar peduncles on MRI. However, further diagnostic work-up revealed positive anti-amphiphysin antibodies in blood and cerebrospinal fluid and subsequently breast cancer. This report of a paraneoplastic rhombencephalitis which initially mimicked MSA-C imaging features stresses the importance of considering immune-mediated rhombencephalitis as differential diagnosis in cases of progressive cerebellar ataxia and the HCB sign on T2-weighted MRI, especially in the absence of pontocerebellar atrophy.
000151540 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
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000151540 650_2 $$2MeSH$$aBreast Neoplasms
000151540 650_2 $$2MeSH$$aCerebellar Ataxia: diagnosis
000151540 650_2 $$2MeSH$$aCerebellar Ataxia: diagnostic imaging
000151540 650_2 $$2MeSH$$aCerebellar Diseases: diagnostic imaging
000151540 650_2 $$2MeSH$$aCerebellum: diagnostic imaging
000151540 650_2 $$2MeSH$$aDiagnosis, Differential
000151540 650_2 $$2MeSH$$aFemale
000151540 650_2 $$2MeSH$$aHumans
000151540 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000151540 650_2 $$2MeSH$$aMale
000151540 650_2 $$2MeSH$$aMiddle Aged
000151540 650_2 $$2MeSH$$aMiddle Cerebellar Peduncle: diagnostic imaging
000151540 650_2 $$2MeSH$$aMultiple System Atrophy: diagnosis
000151540 650_2 $$2MeSH$$aMultiple System Atrophy: diagnostic imaging
000151540 650_2 $$2MeSH$$aSpinocerebellar Degenerations: diagnostic imaging
000151540 7001_ $$aKeil, Vera C.$$b1
000151540 7001_ $$aPaus, Marie$$b2
000151540 7001_ $$aKornblum, Cornelia$$b3
000151540 7001_ $$aHattingen, Elke$$b4
000151540 7001_ $$0P:(DE-2719)2810314$$aKlockgether, Thomas$$b5$$eLast author
000151540 77318 $$2Crossref$$3journal-article$$a10.1016/j.jocn.2020.04.052$$b : Elsevier BV, 2020-06-01$$p238-240$$tJournal of Clinical Neuroscience$$v76$$x0967-5868$$y2020
000151540 773__ $$0PERI:(DE-600)2009190-4$$a10.1016/j.jocn.2020.04.052$$gVol. 76, p. 238 - 240$$p238-240$$tJournal of clinical neuroscience$$v76$$x0967-5868$$y2020
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