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024 7 _ |a 10.1016/j.jocn.2020.04.052
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024 7 _ |a 0967-5868
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041 _ _ |a English
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100 1 _ |a Schlapakow, Elena
|b 0
245 _ _ |a Multiple system atrophy mimicry in MRI: Watch out for paraneoplastic rhombencephalitis
260 _ _ |a Burlington, Mass.
|c 2020
|b Harcourt
264 _ 1 |3 print
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|b Elsevier BV
|c 2020-06-01
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520 _ _ |a The hot cross bun (HCB) sign describes cruciform-shaped T2-weighted hyperintensities of pontocerebellar fibers within the pons and is a typical, but not specific imaging hallmark of the cerebellar variant of multiple system atrophy (MSA-C). We report a case of a 51-year-old woman who was first diagnosed with MSA-C based on progressive cerebellar ataxia, the HCB sign and T2-weighted hyperintensities in middle cerebellar peduncles on MRI. However, further diagnostic work-up revealed positive anti-amphiphysin antibodies in blood and cerebrospinal fluid and subsequently breast cancer. This report of a paraneoplastic rhombencephalitis which initially mimicked MSA-C imaging features stresses the importance of considering immune-mediated rhombencephalitis as differential diagnosis in cases of progressive cerebellar ataxia and the HCB sign on T2-weighted MRI, especially in the absence of pontocerebellar atrophy.
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650 _ 2 |a Breast Neoplasms
|2 MeSH
650 _ 2 |a Cerebellar Ataxia: diagnosis
|2 MeSH
650 _ 2 |a Cerebellar Ataxia: diagnostic imaging
|2 MeSH
650 _ 2 |a Cerebellar Diseases: diagnostic imaging
|2 MeSH
650 _ 2 |a Cerebellum: diagnostic imaging
|2 MeSH
650 _ 2 |a Diagnosis, Differential
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Middle Cerebellar Peduncle: diagnostic imaging
|2 MeSH
650 _ 2 |a Multiple System Atrophy: diagnosis
|2 MeSH
650 _ 2 |a Multiple System Atrophy: diagnostic imaging
|2 MeSH
650 _ 2 |a Spinocerebellar Degenerations: diagnostic imaging
|2 MeSH
700 1 _ |a Keil, Vera C.
|b 1
700 1 _ |a Paus, Marie
|b 2
700 1 _ |a Kornblum, Cornelia
|b 3
700 1 _ |a Hattingen, Elke
|b 4
700 1 _ |a Klockgether, Thomas
|0 P:(DE-2719)2810314
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773 1 8 |a 10.1016/j.jocn.2020.04.052
|b : Elsevier BV, 2020-06-01
|p 238-240
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|t Journal of Clinical Neuroscience
|v 76
|y 2020
|x 0967-5868
773 _ _ |a 10.1016/j.jocn.2020.04.052
|g Vol. 76, p. 238 - 240
|0 PERI:(DE-600)2009190-4
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|t Journal of clinical neuroscience
|v 76
|y 2020
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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