000151578 001__ 151578 000151578 005__ 20240423115945.0 000151578 0247_ $$2pmc$$apmc:PMC7250899 000151578 0247_ $$2doi$$a10.1038/s41467-020-15805-9 000151578 0247_ $$2altmetric$$aaltmetric:82749629 000151578 0247_ $$2pmid$$apmid:32457293 000151578 037__ $$aDZNE-2020-01162 000151578 041__ $$aEnglish 000151578 082__ $$a500 000151578 1001_ $$0P:(DE-2719)2810620$$aStangl, Matthias$$b0$$eFirst author$$udzne 000151578 245__ $$aSources of path integration error in young and aging humans 000151578 260__ $$a[London]$$bNature Publishing Group UK$$c2020 000151578 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2020-05-26 000151578 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2020-12-01 000151578 3367_ $$2DRIVER$$aarticle 000151578 3367_ $$2DataCite$$aOutput Types/Journal article 000151578 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1713781627_6653 000151578 3367_ $$2BibTeX$$aARTICLE 000151578 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000151578 3367_ $$00$$2EndNote$$aJournal Article 000151578 520__ $$aPath integration plays a vital role in navigation: it enables the continuous tracking of one's position in space by integrating self-motion cues. Path integration abilities vary widely across individuals, and tend to deteriorate in old age. The specific causes of path integration errors, however, remain poorly characterized. Here, we combine tests of path integration performance in participants of different ages with an analysis based on the Langevin equation for diffusive dynamics, which allows us to decompose errors into distinct causes that can corrupt path integration computations. We show that, across age groups, the dominant error source is unbiased noise that accumulates with travel distance not elapsed time, suggesting that the noise originates in the velocity input rather than within the integrator. Age-related declines are primarily traced to a growth in this noise. These findings shed light on the contributors to path integration error and the mechanisms underlying age-related navigational deficits. 000151578 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0 000151578 542__ $$2Crossref$$i2020-05-26$$uhttps://creativecommons.org/licenses/by/4.0 000151578 588__ $$aDataset connected to CrossRef 000151578 650_2 $$2MeSH$$aAdult 000151578 650_2 $$2MeSH$$aAged 000151578 650_2 $$2MeSH$$aCognitive Aging: physiology 000151578 650_2 $$2MeSH$$aDistance Perception: physiology 000151578 650_2 $$2MeSH$$aFemale 000151578 650_2 $$2MeSH$$aHumans 000151578 650_2 $$2MeSH$$aMale 000151578 650_2 $$2MeSH$$aMiddle Aged 000151578 650_2 $$2MeSH$$aModels, Neurological 000151578 650_2 $$2MeSH$$aSpatial Memory: physiology 000151578 650_2 $$2MeSH$$aSpatial Navigation: physiology 000151578 650_2 $$2MeSH$$aSpatial Processing: physiology 000151578 650_2 $$2MeSH$$aWalking: physiology 000151578 650_2 $$2MeSH$$aYoung Adult 000151578 7001_ $$aKanitscheider, Ingmar$$b1 000151578 7001_ $$0P:(DE-2719)2813753$$aRiemer, Martin$$b2$$udzne 000151578 7001_ $$00000-0003-4738-2539$$aFiete, Ila$$b3 000151578 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b4$$eLast author$$udzne 000151578 77318 $$2Crossref$$3journal-article$$a10.1038/s41467-020-15805-9$$b : Springer Science and Business Media LLC, 2020-05-26$$n1$$p2626$$tNature Communications$$v11$$x2041-1723$$y2020 000151578 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-020-15805-9$$gVol. 11, no. 1, p. 2626$$n1$$p2626$$tNature Communications$$v11$$x2041-1723$$y2020 000151578 8564_ $$uhttps://www.nature.com/articles/s41467-020-15805-9 000151578 8564_ $$uhttps://pub.dzne.de/record/151578/files/DZNE-2020-01162.pdf$$yOpenAccess 000151578 8564_ $$uhttps://pub.dzne.de/record/151578/files/DZNE-2020-01162.pdf?subformat=pdfa$$xpdfa$$yOpenAccess 000151578 909CO $$ooai:pub.dzne.de:151578$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery 000151578 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810620$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE 000151578 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2813753$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE 000151578 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810583$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE 000151578 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0 000151578 9141_ $$y2020 000151578 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-11 000151578 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2020-01-16 000151578 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-01-16 000151578 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bNAT COMMUN : 2021$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2021$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-10-13T14:44:21Z 000151578 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-10-13T14:44:21Z 000151578 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess 000151578 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Peer review$$d2021-10-13T14:44:21Z 000151578 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$f2020-01-16 000151578 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-01-16 000151578 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2022-11-11 000151578 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-01-16 000151578 9201_ $$0I:(DE-2719)1310002$$kAG Wolbers$$lAging, Cognition and Technology$$x0 000151578 980__ $$ajournal 000151578 980__ $$aVDB 000151578 980__ $$aUNRESTRICTED 000151578 980__ $$aI:(DE-2719)1310002 000151578 9801_ $$aFullTexts 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3758/s13423-015-0952-y$$o10.3758/s13423-015-0952-y 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.3304$$o10.1038/nn.3304 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1037/xlm0000654$$o10.1037/xlm0000654 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2017.06.037$$o10.1016/j.neuron.2017.06.037 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hipo.10173$$o10.1002/hipo.10173 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1146/annurev.neuro.29.051605.112953$$o10.1146/annurev.neuro.29.051605.112953 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.21-15-05740.2001$$o10.1523/JNEUROSCI.21-15-05740.2001 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.brainres.2006.03.101$$o10.1016/j.brainres.2006.03.101 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1152/jn.00295.2012$$o10.1152/jn.00295.2012 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.3254-14.2015$$o10.1523/JNEUROSCI.3254-14.2015 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2011.12.001$$o10.1016/j.tins.2011.12.001 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1146/annurev.neuro.31.060407.125555$$o10.1146/annurev.neuro.31.060407.125555 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1037/0096-3445.122.1.73$$o10.1037/0096-3445.122.1.73 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1023/A:1010061313300$$o10.1023/A:1010061313300 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/ENEURO.0346-16.2017$$o10.1523/ENEURO.0346-16.2017 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1233912$$o10.1126/science.1233912 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00221-006-0835-6$$o10.1007/s00221-006-0835-6 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00221-011-2696-x$$o10.1007/s00221-011-2696-x 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2018.05.040$$o10.1016/j.neuron.2018.05.040 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3758/BF03194870$$o10.3758/BF03194870 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.bbr.2009.08.001$$o10.1016/j.bbr.2009.08.001 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnagi.2012.00026$$o10.3389/fnagi.2012.00026 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hipo.22011$$o10.1002/hipo.22011 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2014.04.003$$o10.1016/j.neurobiolaging.2014.04.003 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cognition.2007.06.004$$o10.1016/j.cognition.2007.06.004 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1037/0033-295X.86.5.415$$o10.1037/0033-295X.86.5.415 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1152/jn.2002.88.3.1533$$o10.1152/jn.2002.88.3.1533 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn2258$$o10.1038/nrn2258 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1117386109$$o10.1073/pnas.1117386109 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.10-02-00436.1990$$o10.1523/JNEUROSCI.10-02-00436.1990 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.15-01-00070.1995$$o10.1523/JNEUROSCI.15-01-00070.1995 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.15-03-01648.1995$$o10.1523/JNEUROSCI.15-03-01648.1995 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.0693-05.2005$$o10.1523/JNEUROSCI.0693-05.2005 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.3884$$o10.1038/nn.3884 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2028-11.2011$$o10.1523/JNEUROSCI.2028-11.2011 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tics.2015.03.002$$o10.1016/j.tics.2015.03.002 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/cercor/10.9.910$$o10.1093/cercor/10.9.910 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0959-4388(03)00050-3$$o10.1016/S0959-4388(03)00050-3 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s10827-005-6559-y$$o10.1007/s10827-005-6559-y 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1162/neco.2008.10-06-378$$o10.1162/neco.2008.10-06-378 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pcbi.1000291$$o10.1371/journal.pcbi.1000291 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrn1804$$o10.1038/nrn1804 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00221-011-2568-4$$o10.1007/s00221-011-2568-4 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2094-13.2013$$o10.1523/JNEUROSCI.2094-13.2013 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnbeh.2018.00036$$o10.3389/fnbeh.2018.00036 000151578 999C5 $$2Crossref$$o 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2018.02.038$$o10.1016/j.cub.2018.02.038 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/s41593-017-0039-3$$o10.1038/s41593-017-0039-3 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1532-5415.2005.53221.x$$o10.1111/j.1532-5415.2005.53221.x 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/gps.2101$$o10.1002/gps.2101 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1538-4632.1993.tb00300.x$$o10.1111/j.1538-4632.1993.tb00300.x 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00221-010-2460-7$$o10.1007/s00221-010-2460-7 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1177/0013916589213006$$o10.1177/0013916589213006 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1037/h0056345$$o10.1037/h0056345 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2307/1420251$$o10.2307/1420251 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1364/JOSA.55.001303$$o10.1364/JOSA.55.001303 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3758/BF03207390$$o10.3758/BF03207390 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1103/PhysRev.36.823$$o10.1103/PhysRev.36.823 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/978-1-4939-1323-7$$o10.1007/978-1-4939-1323-7 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/978-0-387-71887-3$$o10.1007/978-0-387-71887-3 000151578 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.2307/271063$$o10.2307/271063