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000151587 041__ $$aEnglish
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000151587 1001_ $$0P:(DE-2719)2810799$$aBillette, Ornella V.$$b0$$eFirst author$$udzne
000151587 245__ $$aThe concept of regularization: Resolving the problem of surface dyslexia in semantic variant primary progressive aphasia across different languages.
000151587 260__ $$aWashington, DC$$bAssoc.$$c2020
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000151587 520__ $$aSurface dyslexia, a diagnostic feature of the semantic variant of primary progressive aphasia (svPPA), is difficult to observe in many languages. It can be conceptualized as one manifestation of a more general “regularization” effect—that is, with semantic impairment, patients fail to recognize exceptions and revert to default rules. Objective: We predicted that, analogous to surface dyslexia in English, German patients with svPPA would regularize irregular verbs, especially those of lower frequency and in the less frequently used preterite tense. Method: Regularization was investigated in German through past-tense verb inflectional morphology in N = 10 svPPA, N = 5 PPA related to Alzheimer pathology (Aß+PPA), N = 5 patients with nonfluent variant PPA (nfvPPA), N = 12 typical (amnestic presentation) Alzheimer’s disease (AD), and N = 32 healthy controls. The task involved perfect- and preterite-tense inflection of regular and irregular verbs of high and low frequency. Results: Errors in svPPA particularly involved regularization (e.g., I swim → I swimmed, I have swimmed), whereas Aß+PPA made a wide range of other errors (e.g., verb agreement or tense errors). Regularization was rare in AD and controls, whereas the expected frequency effects (low worse than high) were found in svPPA. nfvPPA had profound difficulties in inflecting verbs in general. Conclusion: The study illustrates how tests tailored to a specific language can reveal the regularization effect of svPPA. For more universal diagnostic recommendations, future revisions for svPPA should consider substituting the criterion of surface dyslexia for that of a general criterion of regularization of language rules, the former being an example of the latter. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
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000151587 650_2 $$2MeSH$$aAged
000151587 650_2 $$2MeSH$$aAged, 80 and over
000151587 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000151587 650_2 $$2MeSH$$aAlzheimer Disease: psychology
000151587 650_2 $$2MeSH$$aAphasia, Primary Progressive: psychology
000151587 650_2 $$2MeSH$$aAphasia, Primary Progressive: therapy
000151587 650_2 $$2MeSH$$aDyslexia: psychology
000151587 650_2 $$2MeSH$$aDyslexia: therapy
000151587 650_2 $$2MeSH$$aFemale
000151587 650_2 $$2MeSH$$aHumans
000151587 650_2 $$2MeSH$$aLanguage
000151587 650_2 $$2MeSH$$aMale
000151587 650_2 $$2MeSH$$aMiddle Aged
000151587 650_2 $$2MeSH$$aPsychomotor Performance
000151587 650_2 $$2MeSH$$aSemantics
000151587 7001_ $$0P:(DE-2719)2810729$$aPreiß, Daniel$$b1$$udzne
000151587 7001_ $$0P:(DE-2719)2810673$$aNestor, Peter J.$$b2$$eLast author$$udzne
000151587 77318 $$2Crossref$$3journal-article$$a10.1037/neu0000611$$b : American Psychological Association (APA), 2020-03-01$$n3$$p298-307$$tNeuropsychology$$v34$$x1931-1559$$y2020
000151587 773__ $$0PERI:(DE-600)2102776-6$$a10.1037/neu0000611$$gVol. 34, no. 3, p. 298 - 307$$n3$$p298-307$$tNeuropsychology$$v34$$x1931-1559$$y2020
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