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000151596 0247_ $$2doi$$a10.1093/cercor/bhz313
000151596 0247_ $$2ISSN$$a1047-3211
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000151596 041__ $$aEnglish
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000151596 1001_ $$0P:(DE-2719)9000985$$aPerosa, Valentina$$b0$$eFirst author$$udzne
000151596 245__ $$aThe Role of the Striatum in Learning to Orthogonalize Action and Valence: A Combined PET and 7 T MRI Aging Study
000151596 260__ $$aOxford$$bOxford Univ. Press$$c2020
000151596 264_1 $$2Crossref$$3online$$bOxford University Press (OUP)$$c2020-01-02
000151596 264_1 $$2Crossref$$3print$$bOxford University Press (OUP)$$c2020-05-14
000151596 3367_ $$2DRIVER$$aarticle
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000151596 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1709649943_29109
000151596 3367_ $$2BibTeX$$aARTICLE
000151596 3367_ $$2ORCID$$aJOURNAL_ARTICLE
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000151596 520__ $$aPavlovian biases influence instrumental learning by coupling reward seeking with action invigoration and punishment avoidance with action suppression. Using a probabilistic go/no-go task designed to orthogonalize action (go/no-go) and valence (reward/punishment), recent studies have shown that the interaction between the two is dependent on the striatum and its key neuromodulator dopamine. Using this task, we sought to identify how structural and neuromodulatory age-related differences in the striatum may influence Pavlovian biases and instrumental learning in 25 young and 31 older adults. Computational modeling revealed a significant age-related reduction in reward and punishment sensitivity and marked (albeit not significant) reduction in learning rate and lapse rate (irreducible noise). Voxel-based morphometry analysis using 7 Tesla MRI images showed that individual differences in learning rate in older adults were related to the volume of the caudate nucleus. In contrast, dopamine synthesis capacity in the dorsal striatum, assessed using [18F]-DOPA positron emission tomography in 22 of these older adults, was not associated with learning performance and did not moderate the relationship between caudate volume and learning rate. This multiparametric approach suggests that age-related differences in striatal volume may influence learning proficiency in old age.
000151596 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000151596 542__ $$2Crossref$$i2020-01-02$$uhttps://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
000151596 588__ $$aDataset connected to CrossRef
000151596 650_2 $$2MeSH$$aAdult
000151596 650_2 $$2MeSH$$aAged
000151596 650_2 $$2MeSH$$aAging: metabolism
000151596 650_2 $$2MeSH$$aAging: physiology
000151596 650_2 $$2MeSH$$aCaudate Nucleus: diagnostic imaging
000151596 650_2 $$2MeSH$$aCaudate Nucleus: metabolism
000151596 650_2 $$2MeSH$$aCaudate Nucleus: pathology
000151596 650_2 $$2MeSH$$aCaudate Nucleus: physiology
000151596 650_2 $$2MeSH$$aConditioning, Operant: physiology
000151596 650_2 $$2MeSH$$aDihydroxyphenylalanine: analogs & derivatives
000151596 650_2 $$2MeSH$$aDopamine: metabolism
000151596 650_2 $$2MeSH$$aFemale
000151596 650_2 $$2MeSH$$aHumans
000151596 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000151596 650_2 $$2MeSH$$aMale
000151596 650_2 $$2MeSH$$aMiddle Aged
000151596 650_2 $$2MeSH$$aNeostriatum: diagnostic imaging
000151596 650_2 $$2MeSH$$aNeostriatum: metabolism
000151596 650_2 $$2MeSH$$aNeostriatum: pathology
000151596 650_2 $$2MeSH$$aNeostriatum: physiology
000151596 650_2 $$2MeSH$$aOrgan Size
000151596 650_2 $$2MeSH$$aPositron-Emission Tomography
000151596 650_2 $$2MeSH$$aPunishment
000151596 650_2 $$2MeSH$$aReward
000151596 650_2 $$2MeSH$$aYoung Adult
000151596 7001_ $$ade Boer, Lieke$$b1
000151596 7001_ $$0P:(DE-2719)2814076$$aZiegler, Gabriel$$b2$$udzne
000151596 7001_ $$aApostolova, Ivayla$$b3
000151596 7001_ $$aBuchert, Ralph$$b4
000151596 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline$$b5$$udzne
000151596 7001_ $$aAmthauer, Holger$$b6
000151596 7001_ $$aGuitart-Masip, Marc$$b7
000151596 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b8$$udzne
000151596 7001_ $$0P:(DE-2719)2810555$$aBetts, Matthew$$b9$$eLast author$$udzne
000151596 77318 $$2Crossref$$3journal-article$$a10.1093/cercor/bhz313$$b : Oxford University Press (OUP), 2020-01-02$$n5$$p3340-3351$$tCerebral Cortex$$v30$$x1047-3211$$y2020
000151596 773__ $$0PERI:(DE-600)1483485-6$$a10.1093/cercor/bhz313$$gVol. 30, no. 5, p. 3340 - 3351$$n5$$p3340-3351$$tCerebral cortex$$v30$$x1047-3211$$y2020
000151596 8564_ $$uhttps://academic.oup.com/cercor/article/30/5/3340/5688723
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000151596 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000985$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
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000151596 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0
000151596 9141_ $$y2020
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000151596 999C5 $$2Crossref$$oAntonini 1993$$y1993
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2007.07.007$$o10.1016/j.neuroimage.2007.07.007
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.4506$$o10.1038/nn.4506
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2009.10.018$$o10.1016/j.neurobiolaging.2009.10.018
000151596 999C5 $$2Crossref$$oBates Fitting Linear Mixed-Effects Models using lme4 2014$$tFitting Linear Mixed-Effects Models using lme4$$y2014
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1207/s15327752jpa6703_13$$o10.1207/s15327752jpa6703_13
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.media.2005.09.004$$o10.1016/j.media.2005.09.004
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2016.05.024$$o10.1016/j.neuroimage.2016.05.024
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.5754-12.2013$$o10.1523/JNEUROSCI.5754-12.2013
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3171/2010.3.JNS091385$$o10.3171/2010.3.JNS091385
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.3364$$o10.1038/nn.3364
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2013.03.030$$o10.1016/j.neurobiolaging.2013.03.030
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4467-08.2009$$o10.1523/JNEUROSCI.4467-08.2009
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2711-11.2011$$o10.1523/JNEUROSCI.2711-11.2011
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1146/annurev.neuro.051508.135607$$o10.1146/annurev.neuro.051508.135607
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.conb.2008.08.003$$o10.1016/j.conb.2008.08.003
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neunet.2006.03.002$$o10.1016/j.neunet.2006.03.002
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1816704116$$o10.1073/pnas.1816704116
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2012.09.055$$o10.1016/j.neuroimage.2012.09.055
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2013.08.030$$o10.1016/j.neuron.2013.08.030
000151596 999C5 $$2Crossref$$oDi 2014$$y2014
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0802127105$$o10.1073/pnas.0802127105
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2011.10.065$$o10.1016/j.neuroimage.2011.10.065
000151596 999C5 $$2Crossref$$oEisenegger Neuropsychopharmacology 2014$$tNeuropsychopharmacology$$y2014
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2942-12.2013$$o10.1523/JNEUROSCI.2942-12.2013
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.pscychresns.2004.09.005$$o10.1016/j.pscychresns.2004.09.005
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2736-05.2005$$o10.1523/JNEUROSCI.2736-05.2005
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0022-3956(75)90026-6$$o10.1016/0022-3956(75)90026-6
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/1471-2202-3-14$$o10.1186/1471-2202-3-14
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1162/0898929052880093$$o10.1162/0898929052880093
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1102941$$o10.1126/science.1102941
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1037/0096-1523.8.6.875$$o10.1037/0096-1523.8.6.875
000151596 999C5 $$2Crossref$$oGrady 2013$$y2013
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.1202229109$$o10.1073/pnas.1202229109
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tics.2014.01.003$$o10.1016/j.tics.2014.01.003
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00213-013-3313-4$$o10.1007/s00213-013-3313-4
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.6376-10.2011$$o10.1523/JNEUROSCI.6376-10.2011
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2012.04.024$$o10.1016/j.neuroimage.2012.04.024
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/npp.2009.129$$o10.1038/npp.2009.129
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/jcbfm.1993.8$$o10.1038/jcbfm.1993.8
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pcbi.1002028$$o10.1371/journal.pcbi.1002028
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1080/01621459.1995.10476572$$o10.1080/01621459.1995.10476572
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn.3100$$o10.1038/nn.3100
000151596 999C5 $$2Crossref$$oLeclercq Applied Neuropsychology of attention: Theory, Diagnosis and Rehabilitation 2004$$tApplied Neuropsychology of attention: Theory, Diagnosis and Rehabilitation$$y2004
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4561-14.2015$$o10.1523/JNEUROSCI.4561-14.2015
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tics.2012.07.007$$o10.1016/j.tics.2012.07.007
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.aal3618$$o10.1126/science.aal3618
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1053-8119(03)00169-1$$o10.1016/S1053-8119(03)00169-1
000151596 999C5 $$2Crossref$$oMechelli Current Medical Imaging Reviews 2005$$tCurrent Medical Imaging Reviews$$y2005
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuropsychologia.2004.07.010$$o10.1016/j.neuropsychologia.2004.07.010
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/neuro.09.034.2009$$o10.3389/neuro.09.034.2009
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neubiorev.2009.05.010$$o10.1016/j.neubiorev.2009.05.010
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00213-006-0502-4$$o10.1007/s00213-006-0502-4
000151596 999C5 $$2Crossref$$oO’Doherty 2004$$y2004
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2011.02.046$$o10.1016/j.neuroimage.2011.02.046
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/jcbfm.1985.87$$o10.1038/jcbfm.1985.87
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature05051$$o10.1038/nature05051
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnhum.2014.00876$$o10.3389/fnhum.2014.00876
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn2061$$o10.1038/nn2061
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnsys.2014.00140$$o10.3389/fnsys.2014.00140
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2012.10.021$$o10.1016/j.neuron.2012.10.021
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4902-09.2010$$o10.1523/JNEUROSCI.4902-09.2010
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3758/s13415-014-0297-4$$o10.3758/s13415-014-0297-4
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1115270$$o10.1126/science.1115270
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pbio.1001266$$o10.1371/journal.pbio.1001266
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/brain/awm147$$o10.1093/brain/awm147
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1152/jn.1998.80.1.1$$o10.1152/jn.1998.80.1.1
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(02)00967-4$$o10.1016/S0896-6273(02)00967-4
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2015.03.019$$o10.1016/j.neuroimage.2015.03.019
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2012.03.037$$o10.1016/j.neuron.2012.03.037
000151596 999C5 $$2Crossref$$oShiner 2012$$y2012
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1460-9568.2012.08043.x$$o10.1111/j.1460-9568.2012.08043.x
000151596 999C5 $$2Crossref$$oSutton Sutton & Barto Book: Reinforcement Learning: An Introduction 1998$$tSutton & Barto Book: Reinforcement Learning: An Introduction$$y1998
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0010-9452(08)70958-4$$o10.1016/S0010-9452(08)70958-4
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.7554/eLife.22169$$o10.7554/eLife.22169
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2026-09.2009$$o10.1523/JNEUROSCI.2026-09.2009
000151596 999C5 $$2Crossref$$oTeam RC 2016$$y2016
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnins.2013.00142$$o10.3389/fnins.2013.00142
000151596 999C5 $$2Crossref$$ovan Dyck 1995$$y1995
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1162/jocn_a_01099$$o10.1162/jocn_a_01099
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/hbm.22771$$o10.1002/hbm.22771
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/(SICI)1098-2396(199809)30:1<56::AID-SYN7>3.0.CO;2-J$$o10.1002/(SICI)1098-2396(199809)30:1<56::AID-SYN7>3.0.CO;2-J
000151596 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1901/jeab.1987.48-175$$o10.1901/jeab.1987.48-175