TY  - JOUR
AU  - Perosa, Valentina
AU  - de Boer, Lieke
AU  - Ziegler, Gabriel
AU  - Apostolova, Ivayla
AU  - Buchert, Ralph
AU  - Metzger, Coraline
AU  - Amthauer, Holger
AU  - Guitart-Masip, Marc
AU  - Düzel, Emrah
AU  - Betts, Matthew
TI  - The Role of the Striatum in Learning to Orthogonalize Action and Valence: A Combined PET and 7 T MRI Aging Study
JO  - Cerebral cortex
VL  - 30
IS  - 5
SN  - 1047-3211
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DZNE-2020-01180
SP  - 3340-3351
PY  - 2020
AB  - Pavlovian biases influence instrumental learning by coupling reward seeking with action invigoration and punishment avoidance with action suppression. Using a probabilistic go/no-go task designed to orthogonalize action (go/no-go) and valence (reward/punishment), recent studies have shown that the interaction between the two is dependent on the striatum and its key neuromodulator dopamine. Using this task, we sought to identify how structural and neuromodulatory age-related differences in the striatum may influence Pavlovian biases and instrumental learning in 25 young and 31 older adults. Computational modeling revealed a significant age-related reduction in reward and punishment sensitivity and marked (albeit not significant) reduction in learning rate and lapse rate (irreducible noise). Voxel-based morphometry analysis using 7 Tesla MRI images showed that individual differences in learning rate in older adults were related to the volume of the caudate nucleus. In contrast, dopamine synthesis capacity in the dorsal striatum, assessed using [18F]-DOPA positron emission tomography in 22 of these older adults, was not associated with learning performance and did not moderate the relationship between caudate volume and learning rate. This multiparametric approach suggests that age-related differences in striatal volume may influence learning proficiency in old age.
KW  - Adult
KW  - Aged
KW  - Aging: metabolism
KW  - Aging: physiology
KW  - Caudate Nucleus: diagnostic imaging
KW  - Caudate Nucleus: metabolism
KW  - Caudate Nucleus: pathology
KW  - Caudate Nucleus: physiology
KW  - Conditioning, Operant: physiology
KW  - Dihydroxyphenylalanine: analogs & derivatives
KW  - Dopamine: metabolism
KW  - Female
KW  - Humans
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Neostriatum: diagnostic imaging
KW  - Neostriatum: metabolism
KW  - Neostriatum: pathology
KW  - Neostriatum: physiology
KW  - Organ Size
KW  - Positron-Emission Tomography
KW  - Punishment
KW  - Reward
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:31897476
DO  - DOI:10.1093/cercor/bhz313
UR  - https://pub.dzne.de/record/151596
ER  -