%0 Journal Article
%A Wittfeld, Katharina
%A Jochem, Carmen
%A Dörr, Marcus
%A Schminke, Ulf
%A Gläser, Sven
%A Bahls, Martin
%A Markus, Marcello R P
%A Felix, Stephan B
%A Leitzmann, Michael F
%A Ewert, Ralf
%A Bülow, Robin
%A Völzke, Henry
%A Janowitz, Deborah
%A Baumeister, Sebastian E
%A Grabe, Hans Jörgen
%T Cardiorespiratory Fitness and Gray Matter Volume in the Temporal, Frontal, and Cerebellar Regions in the General Population.
%J Mayo Clinic proceedings
%V 95
%N 1
%@ 0025-6196
%C [S.l.]
%I Elsevier
%M DZNE-2020-01195
%P 44 - 56
%D 2020
%X To analyze the association between cardiorespiratory fitness (CRF) and global and local brain volumes.We studied 2103 adults (21-84 years old) from 2 independent population-based cohorts (Study of Health in Pomerania, examinations from June 25, 2008, through September 30, 2012). Cardiorespiratory fitness was measured using peak oxygen uptake (VO2peak), oxygen uptake at the anaerobic threshold (VO2@AT), and maximal power output from cardiopulmonary exercise testing on a bicycle ergometer. Magnetic resonance imaging brain data were analyzed by voxel-based morphometry using regression models with adjustment for age, sex, education, smoking, body weight, systolic blood pressure, glycated hemoglobin level, and intracranial volume.Volumetric analyses revealed associations of CRF with gray matter (GM) volume and total brain volume. After multivariable adjustment, a 1-standard deviation increase in VO2peak was related to a 5.31 cm³ (95
%K Adult
%K Aged
%K Aged, 80 and over
%K Anaerobic Threshold
%K Brain: diagnostic imaging
%K Brain: pathology
%K Cardiorespiratory Fitness: physiology
%K Correlation of Data
%K Exercise Test: methods
%K Exercise Test: statistics & numerical data
%K Female
%K Gray Matter: diagnostic imaging
%K Gray Matter: pathology
%K Humans
%K Male
%K Middle Aged
%K Organ Size
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31902428
%R 10.1016/j.mayocp.2019.05.030
%U https://pub.dzne.de/record/151613