TY  - JOUR
AU  - Wittfeld, Katharina
AU  - Jochem, Carmen
AU  - Dörr, Marcus
AU  - Schminke, Ulf
AU  - Gläser, Sven
AU  - Bahls, Martin
AU  - Markus, Marcello R P
AU  - Felix, Stephan B
AU  - Leitzmann, Michael F
AU  - Ewert, Ralf
AU  - Bülow, Robin
AU  - Völzke, Henry
AU  - Janowitz, Deborah
AU  - Baumeister, Sebastian E
AU  - Grabe, Hans Jörgen
TI  - Cardiorespiratory Fitness and Gray Matter Volume in the Temporal, Frontal, and Cerebellar Regions in the General Population.
JO  - Mayo Clinic proceedings
VL  - 95
IS  - 1
SN  - 0025-6196
CY  - [S.l.]
PB  - Elsevier
M1  - DZNE-2020-01195
SP  - 44 - 56
PY  - 2020
AB  - To analyze the association between cardiorespiratory fitness (CRF) and global and local brain volumes.We studied 2103 adults (21-84 years old) from 2 independent population-based cohorts (Study of Health in Pomerania, examinations from June 25, 2008, through September 30, 2012). Cardiorespiratory fitness was measured using peak oxygen uptake (VO2peak), oxygen uptake at the anaerobic threshold (VO2@AT), and maximal power output from cardiopulmonary exercise testing on a bicycle ergometer. Magnetic resonance imaging brain data were analyzed by voxel-based morphometry using regression models with adjustment for age, sex, education, smoking, body weight, systolic blood pressure, glycated hemoglobin level, and intracranial volume.Volumetric analyses revealed associations of CRF with gray matter (GM) volume and total brain volume. After multivariable adjustment, a 1-standard deviation increase in VO2peak was related to a 5.31 cm³ (95
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Anaerobic Threshold
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Cardiorespiratory Fitness: physiology
KW  - Correlation of Data
KW  - Exercise Test: methods
KW  - Exercise Test: statistics & numerical data
KW  - Female
KW  - Gray Matter: diagnostic imaging
KW  - Gray Matter: pathology
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Organ Size
LB  - PUB:(DE-HGF)16
C6  - pmid:31902428
DO  - DOI:10.1016/j.mayocp.2019.05.030
UR  - https://pub.dzne.de/record/151613
ER  -