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@ARTICLE{Wittfeld:151613,
      author       = {Wittfeld, Katharina and Jochem, Carmen and Dörr, Marcus
                      and Schminke, Ulf and Gläser, Sven and Bahls, Martin and
                      Markus, Marcello R P and Felix, Stephan B and Leitzmann,
                      Michael F and Ewert, Ralf and Bülow, Robin and Völzke,
                      Henry and Janowitz, Deborah and Baumeister, Sebastian E and
                      Grabe, Hans Jörgen},
      title        = {{C}ardiorespiratory {F}itness and {G}ray {M}atter {V}olume
                      in the {T}emporal, {F}rontal, and {C}erebellar {R}egions in
                      the {G}eneral {P}opulation.},
      journal      = {Mayo Clinic proceedings},
      volume       = {95},
      number       = {1},
      issn         = {0025-6196},
      address      = {[S.l.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-01195},
      pages        = {44 - 56},
      year         = {2020},
      abstract     = {To analyze the association between cardiorespiratory
                      fitness (CRF) and global and local brain volumes.We studied
                      2103 adults (21-84 years old) from 2 independent
                      population-based cohorts (Study of Health in Pomerania,
                      examinations from June 25, 2008, through September 30,
                      2012). Cardiorespiratory fitness was measured using peak
                      oxygen uptake (VO2peak), oxygen uptake at the anaerobic
                      threshold (VO2@AT), and maximal power output from
                      cardiopulmonary exercise testing on a bicycle ergometer.
                      Magnetic resonance imaging brain data were analyzed by
                      voxel-based morphometry using regression models with
                      adjustment for age, sex, education, smoking, body weight,
                      systolic blood pressure, glycated hemoglobin level, and
                      intracranial volume.Volumetric analyses revealed
                      associations of CRF with gray matter (GM) volume and total
                      brain volume. After multivariable adjustment, a 1-standard
                      deviation increase in VO2peak was related to a 5.31 cm³
                      $(95\%$ CI, 3.27 to 7.35 cm³) higher GM volume. Whole-brain
                      voxel-based morphometry analyses revealed significant
                      positive relations between CRF and local GM volumes. The
                      VO2peak was strongly associated with GM volume of the left
                      middle temporal gyrus (228 voxels), the right hippocampal
                      gyrus (146 voxels), the left orbitofrontal cortex (348
                      voxels), and the bilateral cingulate cortex (68 and 43
                      voxels).Cardiorespiratory fitness was positively associated
                      with GM volume, total brain volume, and specific GM and
                      white matter clusters in brain areas not primarily involved
                      in movement processing. These results, from a representative
                      population sample, suggest that CRF might contribute to
                      improved brain health and might, therefore, decelerate
                      pathology-specific GM decrease.},
      keywords     = {Adult / Aged / Aged, 80 and over / Anaerobic Threshold /
                      Brain: diagnostic imaging / Brain: pathology /
                      Cardiorespiratory Fitness: physiology / Correlation of Data
                      / Exercise Test: methods / Exercise Test: statistics $\&$
                      numerical data / Female / Gray Matter: diagnostic imaging /
                      Gray Matter: pathology / Humans / Male / Middle Aged / Organ
                      Size},
      cin          = {AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31902428},
      doi          = {10.1016/j.mayocp.2019.05.030},
      url          = {https://pub.dzne.de/record/151613},
}