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000151645 0247_ $$2doi$$a10.1080/19336896.2020.1729074
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000151645 0247_ $$2ISSN$$a1933-690X
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000151645 037__ $$aDZNE-2020-01224
000151645 041__ $$aEnglish
000151645 082__ $$a570
000151645 1001_ $$0P:(DE-2719)9000012$$aArora, Amandeep Singh$$b0$$eFirst author
000151645 245__ $$aThe role of cellular prion protein in lipid metabolism in the liver.
000151645 260__ $$aLondon [u.a.]$$bTaylor & Francis$$c2020
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000151645 520__ $$aCellular prion protein (PrPC) is a plasma membrane glycophosphatidylinositol-anchored protein and it is involved in multiple functions, including neuroprotection and oxidative stress. So far, most of the PrPC functional research is done in neuronal tissue or cell lines; the role of PrPC in non-neuronal tissues such as liver is only poorly understood. To characterize the role of PrPC in the liver, a proteomics approach was applied in the liver tissue of PrPC knockout mice. The proteome analysis and biochemical validations showed an excessive fat accumulation in the liver of PrPC knockout mice with a change in mRNA expression of genes linked to lipid metabolism. In addition, the higher Bax to Bcl2 ratio, up-regulation of tgfb1 mRNA expression in PrPC knockout mice liver, further showed the evidences of metabolic disease. Over-expression of PrPC in fatty acid-treated AML12 hepatic cell line caused a reduction in excessive intracellular fat accumulation; shows association of PrPC levels and lipid metabolism. Therefore, based on observation of excessive fat globules in the liver of ageing PrPC knockout mice and the reduction of fat accumulation in AML12 cell line with PrPC over-expression, the role of PrPC in lipid metabolism is described.
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000151645 650_2 $$2MeSH$$aAcetyl-CoA Carboxylase: genetics
000151645 650_2 $$2MeSH$$aAcetyl-CoA Carboxylase: metabolism
000151645 650_2 $$2MeSH$$aAdiposity
000151645 650_2 $$2MeSH$$aAnimals
000151645 650_2 $$2MeSH$$aCell Line
000151645 650_2 $$2MeSH$$aElectrophoresis, Gel, Two-Dimensional
000151645 650_2 $$2MeSH$$aFatty Acid Synthases: genetics
000151645 650_2 $$2MeSH$$aFatty Acid Synthases: metabolism
000151645 650_2 $$2MeSH$$aFemale
000151645 650_2 $$2MeSH$$aGene Expression Regulation
000151645 650_2 $$2MeSH$$aLipid Metabolism: genetics
000151645 650_2 $$2MeSH$$aLiver: metabolism
000151645 650_2 $$2MeSH$$aMale
000151645 650_2 $$2MeSH$$aMetabolic Diseases: metabolism
000151645 650_2 $$2MeSH$$aMice, Inbred C57BL
000151645 650_2 $$2MeSH$$aMice, Knockout
000151645 650_2 $$2MeSH$$aPPAR alpha: metabolism
000151645 650_2 $$2MeSH$$aPrion Proteins: metabolism
000151645 650_2 $$2MeSH$$aProteome: metabolism
000151645 650_2 $$2MeSH$$aProteomics
000151645 650_2 $$2MeSH$$aRNA, Messenger: genetics
000151645 650_2 $$2MeSH$$aRNA, Messenger: metabolism
000151645 650_2 $$2MeSH$$aTransforming Growth Factor beta1: genetics
000151645 650_2 $$2MeSH$$aTransforming Growth Factor beta1: metabolism
000151645 650_2 $$2MeSH$$aTriglycerides: metabolism
000151645 7001_ $$0P:(DE-2719)9000358$$aZafar, Saima$$b1
000151645 7001_ $$aLatif, Umair$$b2
000151645 7001_ $$0P:(DE-2719)2811280$$aLlorens, Franc$$b3
000151645 7001_ $$aSabine, Mihm$$b4
000151645 7001_ $$0P:(DE-2719)9000173$$aKumar, Prateek$$b5
000151645 7001_ $$0P:(DE-2719)9000310$$aTahir, Waqas$$b6
000151645 7001_ $$0P:(DE-2719)2811840$$aThüne, Katrin$$b7
000151645 7001_ $$0P:(DE-2719)9000295$$aShafiq, Mohsin$$b8
000151645 7001_ $$0P:(DE-2719)9000287$$aSchmitz, Matthias$$b9
000151645 7001_ $$0P:(DE-2719)2000058$$aZerr, Inga$$b10$$eLast author
000151645 773__ $$0PERI:(DE-600)2267671-5$$a10.1080/19336896.2020.1729074$$gVol. 14, no. 1, p. 95 - 108$$n1$$p95 - 108$$tPrion$$v14$$x1933-690X$$y2020
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