000153265 001__ 153265 000153265 005__ 20230915094009.0 000153265 0247_ $$2pmid$$apmid:32581724 000153265 0247_ $$2doi$$a10.3389/fncir.2020.00020 000153265 0247_ $$2altmetric$$aaltmetric:83975966 000153265 0247_ $$2pmc$$apmc:PMC7291770 000153265 037__ $$aDZNE-2020-01262 000153265 041__ $$aEnglish 000153265 082__ $$a610 000153265 1001_ $$0P:(DE-HGF)0$$aStahn, Alexander Christoph$$b0$$eCorresponding author 000153265 245__ $$aSpatial Updating Depends on Gravity 000153265 260__ $$aLausanne$$bFrontiers Research Foundation$$c2020 000153265 3367_ $$2DRIVER$$aarticle 000153265 3367_ $$2DataCite$$aOutput Types/Journal article 000153265 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1605877865_21602 000153265 3367_ $$2BibTeX$$aARTICLE 000153265 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000153265 3367_ $$00$$2EndNote$$aJournal Article 000153265 520__ $$aAs we move through an environment the positions of surrounding objects relative to our body constantly change. Maintaining orientation requires spatial updating, the continuous monitoring of self-motion cues to update external locations. This ability critically depends on the integration of visual, proprioceptive, kinesthetic, and vestibular information. During weightlessness gravity no longer acts as an essential reference, creating a discrepancy between vestibular, visual and sensorimotor signals. Here, we explore the effects of repeated bouts of microgravity and hypergravity on spatial updating performance during parabolic flight. Ten healthy participants (four women, six men) took part in a parabolic flight campaign that comprised a total of 31 parabolas. Each parabola created about 20–25 s of 0 g, preceded and followed by about 20 s of hypergravity (1.8 g). Participants performed a visual-spatial updating task in seated position during 15 parabolas. The task included two updating conditions simulating virtual forward movements of different lengths (short and long), and a static condition with no movement that served as a control condition. Two trials were performed during each phase of the parabola, i.e., at 1 g before the start of the parabola, at 1.8 g during the acceleration phase of the parabola, and during 0 g. Our data demonstrate that 0 g and 1.8 g impaired pointing performance for long updating trials as indicated by increased variability of pointing errors compared to 1 g. In contrast, we found no support for any changes for short updating and static conditions, suggesting that a certain degree of task complexity is required to affect pointing errors. These findings are important for operational requirements during spaceflight because spatial updating is pivotal for navigation when vision is poor or unreliable and objects go out of sight, for example during extravehicular activities in space or the exploration of unfamiliar environments. Future studies should compare the effects on spatial updating during seated and free-floating conditions, and determine at which g-threshold decrements in spatial updating performance emerge. 000153265 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0 000153265 588__ $$aDataset connected to CrossRef 000153265 650_2 $$2MeSH$$aAdult 000153265 650_2 $$2MeSH$$aFemale 000153265 650_2 $$2MeSH$$aGravitation 000153265 650_2 $$2MeSH$$aGravity Sensing: physiology 000153265 650_2 $$2MeSH$$aHumans 000153265 650_2 $$2MeSH$$aHypergravity 000153265 650_2 $$2MeSH$$aMale 000153265 650_2 $$2MeSH$$aMiddle Aged 000153265 650_2 $$2MeSH$$aOrientation, Spatial: physiology 000153265 650_2 $$2MeSH$$aSpace Flight: methods 000153265 650_2 $$2MeSH$$aSpace Flight: psychology 000153265 650_2 $$2MeSH$$aSpatial Navigation: physiology 000153265 650_2 $$2MeSH$$aWeightlessness 000153265 7001_ $$0P:(DE-2719)2813753$$aRiemer, Martin$$b1$$udzne 000153265 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b2$$udzne 000153265 7001_ $$aWerner, Anika$$b3 000153265 7001_ $$aBrauns, Katharina$$b4 000153265 7001_ $$aBesnard, Stephane$$b5 000153265 7001_ $$aDenise, Pierre$$b6 000153265 7001_ $$aKühn, Simone$$b7 000153265 7001_ $$aGunga, Hanns-Christian$$b8 000153265 773__ $$0PERI:(DE-600)2452968-0$$a10.3389/fncir.2020.00020$$gVol. 14, p. 20$$p20$$tFrontiers in neural circuits$$v14$$x1662-5110$$y2020 000153265 8564_ $$uhttps://www.frontiersin.org/articles/10.3389/fncir.2020.00020/full 000153265 8564_ $$uhttps://pub.dzne.de/record/153265/files/7023.pdf$$yOpenAccess 000153265 8564_ $$uhttps://pub.dzne.de/record/153265/files/7023.gif?subformat=icon$$xicon$$yOpenAccess 000153265 8564_ $$uhttps://pub.dzne.de/record/153265/files/7023.jpg?subformat=icon-1440$$xicon-1440$$yOpenAccess 000153265 8564_ $$uhttps://pub.dzne.de/record/153265/files/7023.jpg?subformat=icon-180$$xicon-180$$yOpenAccess 000153265 8564_ $$uhttps://pub.dzne.de/record/153265/files/7023.jpg?subformat=icon-640$$xicon-640$$yOpenAccess 000153265 8564_ $$uhttps://pub.dzne.de/record/153265/files/7023.pdf?subformat=pdfa$$xpdfa$$yOpenAccess 000153265 909CO $$ooai:pub.dzne.de:153265$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire 000153265 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2813753$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE 000153265 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810583$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE 000153265 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0 000153265 9141_ $$y2020 000153265 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2020-09-09 000153265 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-09-09 000153265 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-09-09 000153265 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-09-09 000153265 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess 000153265 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2020-09-09 000153265 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFRONT NEURAL CIRCUIT : 2021$$d2022-11-19 000153265 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-19 000153265 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-19 000153265 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-05-11T13:05:11Z 000153265 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-05-11T13:05:11Z 000153265 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2021-05-11T13:05:11Z 000153265 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-19 000153265 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-19 000153265 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2022-11-19 000153265 9201_ $$0I:(DE-2719)1710012$$kAG Falkenburger$$lClinical Study Team Dresden$$x0 000153265 9201_ $$0I:(DE-2719)1310002$$kAG Wolbers$$lAging & Cognition$$x1 000153265 980__ $$ajournal 000153265 980__ $$aVDB 000153265 980__ $$aUNRESTRICTED 000153265 980__ $$aI:(DE-2719)1710012 000153265 980__ $$aI:(DE-2719)1310002 000153265 9801_ $$aFullTexts