TY  - JOUR
AU  - Eckenweber, Florian
AU  - Medina-Luque, Jose
AU  - Blume, Tanja
AU  - Sacher, Christian
AU  - Biechele, Gloria
AU  - Wind, Karin
AU  - Deussing, Maximilian
AU  - Briel, Nils
AU  - Lindner, Simon
AU  - Boening, Guido
AU  - von Ungern-Sternberg, Barbara
AU  - Unterrainer, Marcus
AU  - Albert, Nathalie L.
AU  - Zwergal, Andreas
AU  - Levin, Johannes
AU  - Bartenstein, Peter
AU  - Cumming, Paul
AU  - Rominger, Axel
AU  - Höglinger, Günter U.
AU  - Herms, Jochen
AU  - Brendel, Matthias
TI  - Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning
JO  - Journal of neuroinflammation
VL  - 17
IS  - 1
SN  - 1742-2094
CY  - London
PB  - BioMed Central
M1  - DZNE-2020-01284
SP  - 208
PY  - 2020
AB  - BackgroundP301S tau transgenic mice show age-dependent accumulation of neurofibrillary tangles in the brainstem, hippocampus, and neocortex, leading to neuronal loss and cognitive deterioration. However, there is hitherto only sparse documentation of the role of neuroinflammation in tau mouse models. Thus, we analyzed longitudinal microglial activation by small animal 18 kDa translocator protein positron-emission-tomography (TSPO μPET) imaging in vivo, in conjunction with terminal assessment of tau pathology, spatial learning, and cerebral glucose metabolism.MethodsTransgenic P301S (n = 33) and wild-type (n = 18) female mice were imaged by 18F-GE-180 TSPO μPET at the ages of 1.9, 3.9, and 6.4 months. We conducted behavioral testing in the Morris water maze, 18F-fluordesoxyglucose (18F-FDG) μPET, and AT8 tau immunohistochemistry at 6.3–6.7 months. Terminal microglial immunohistochemistry served for validation of TSPO μPET results in vivo, applying target regions in the brainstem, cortex, cerebellum, and hippocampus. We compared the results with our historical data in amyloid-β mouse models.ResultsTSPO expression in all target regions of P301S mice increased exponentially from 1.9 to 6.4 months, leading to significant differences in the contrasts with wild-type mice at 6.4 months (+ 11–23
LB  - PUB:(DE-HGF)16
C6  - pmid:32660586
DO  - DOI:10.1186/s12974-020-01883-5
UR  - https://pub.dzne.de/record/153287
ER  -