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000153289 0247_ $$2doi$$a10.1038/s41398-020-0842-6
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000153289 037__ $$aDZNE-2020-01286
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000153289 1001_ $$00000-0001-9822-048X$$aSchmaal, Lianne$$b0$$eCorresponding author
000153289 245__ $$aENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
000153289 260__ $$aLondon$$bNature Publishing Group$$c2020
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000153289 520__ $$aA key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.
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000153289 650_2 $$2MeSH$$aBrain: diagnostic imaging
000153289 650_2 $$2MeSH$$aDepression
000153289 650_2 $$2MeSH$$aDepressive Disorder, Major: diagnostic imaging
000153289 650_2 $$2MeSH$$aHumans
000153289 650_2 $$2MeSH$$aInformation Dissemination
000153289 650_2 $$2MeSH$$aNeuroimaging
000153289 7001_ $$aPozzi, Elena$$b1
000153289 7001_ $$aC. Ho, Tiffany$$b2
000153289 7001_ $$avan Velzen, Laura S.$$b3
000153289 7001_ $$aVeer, Ilya M.$$b4
000153289 7001_ $$aOpel, Nils$$b5
000153289 7001_ $$aVan Someren, Eus J. W.$$b6
000153289 7001_ $$00000-0001-9647-3723$$aHan, Laura K. M.$$b7
000153289 7001_ $$aAftanas, Lybomir$$b8
000153289 7001_ $$aAleman, André$$b9
000153289 7001_ $$aBaune, Bernhard T.$$b10
000153289 7001_ $$aBerger, Klaus$$b11
000153289 7001_ $$aBlanken, Tessa F.$$b12
000153289 7001_ $$00000-0003-3117-5156$$aCapitão, Liliana$$b13
000153289 7001_ $$aCouvy-Duchesne, Baptiste$$b14
000153289 7001_ $$aR. Cullen, Kathryn$$b15
000153289 7001_ $$aDannlowski, Udo$$b16
000153289 7001_ $$00000-0003-1431-3852$$aDavey, Christopher$$b17
000153289 7001_ $$aErwin-Grabner, Tracy$$b18
000153289 7001_ $$aEvans, Jennifer$$b19
000153289 7001_ $$0P:(DE-HGF)0$$aFrodl, Thomas$$b20
000153289 7001_ $$aFu, Cynthia H. Y.$$b21
000153289 7001_ $$aGodlewska, Beata$$b22
000153289 7001_ $$aGotlib, Ian H.$$b23
000153289 7001_ $$aGoya-Maldonado, Roberto$$b24
000153289 7001_ $$0P:(DE-2719)2811781$$aGrabe, Hans$$b25$$udzne
000153289 7001_ $$aGroenewold, Nynke A.$$b26
000153289 7001_ $$aGrotegerd, Dominik$$b27
000153289 7001_ $$0P:(DE-HGF)0$$aGruber, Oliver$$b28
000153289 7001_ $$aGutman, Boris A.$$b29
000153289 7001_ $$aHall, Geoffrey B.$$b30
000153289 7001_ $$aHarrison, Ben J.$$b31
000153289 7001_ $$00000-0002-9149-8726$$aHatton, Sean N.$$b32
000153289 7001_ $$aHermesdorf, Marco$$b33
000153289 7001_ $$aHickie, Ian B.$$b34
000153289 7001_ $$aHilland, Eva$$b35
000153289 7001_ $$aIrungu, Benson$$b36
000153289 7001_ $$aJonassen, Rune$$b37
000153289 7001_ $$aKelly, Sinead$$b38
000153289 7001_ $$aKircher, Tilo$$b39
000153289 7001_ $$aKlimes-Dougan, Bonnie$$b40
000153289 7001_ $$00000-0002-0564-2497$$aKrug, Axel$$b41
000153289 7001_ $$aLandrø, Nils Inge$$b42
000153289 7001_ $$aLagopoulos, Jim$$b43
000153289 7001_ $$aLeerssen, Jeanne$$b44
000153289 7001_ $$aLi, Meng$$b45
000153289 7001_ $$00000-0002-5638-9292$$aLinden, David E. J.$$b46
000153289 7001_ $$aMacMaster, Frank P.$$b47
000153289 7001_ $$00000-0002-0198-4588$$aM. McIntosh, Andrew$$b48
000153289 7001_ $$aMehler, David M. A.$$b49
000153289 7001_ $$aNenadić, Igor$$b50
000153289 7001_ $$aPenninx, Brenda W. J. H.$$b51
000153289 7001_ $$aPortella, Maria J.$$b52
000153289 7001_ $$aReneman, Liesbeth$$b53
000153289 7001_ $$00000-0003-4626-7248$$aRentería, Miguel E.$$b54
000153289 7001_ $$aSacchet, Matthew D.$$b55
000153289 7001_ $$aG. Sämann, Philipp$$b56
000153289 7001_ $$aSchrantee, Anouk$$b57
000153289 7001_ $$00000-0003-3209-9626$$aSim, Kang$$b58
000153289 7001_ $$aSoares, Jair C.$$b59
000153289 7001_ $$00000-0001-7218-7810$$aStein, Dan J.$$b60
000153289 7001_ $$00000-0002-9429-6476$$aTozzi, Leonardo$$b61
000153289 7001_ $$avan Der Wee, Nic J. A.$$b62
000153289 7001_ $$00000-0002-9260-5490$$avan Tol, Marie-José$$b63
000153289 7001_ $$aVermeiren, Robert$$b64
000153289 7001_ $$aVives-Gilabert, Yolanda$$b65
000153289 7001_ $$00000-0002-9403-6121$$aWalter, Henrik$$b66
000153289 7001_ $$aWalter, Martin$$b67
000153289 7001_ $$00000-0002-4505-8869$$aWhalley, Heather C.$$b68
000153289 7001_ $$aWittfeld, Katharina$$b69
000153289 7001_ $$aWhittle, Sarah$$b70
000153289 7001_ $$00000-0001-7133-4970$$aWright, Margaret J.$$b71
000153289 7001_ $$aYang, Tony T.$$b72
000153289 7001_ $$aZarate, Carlos$$b73
000153289 7001_ $$aThomopoulos, Sophia I.$$b74
000153289 7001_ $$00000-0003-4401-8950$$aJahanshad, Neda$$b75
000153289 7001_ $$aThompson, Paul M.$$b76
000153289 7001_ $$aVeltman, Dick J.$$b77
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