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@ARTICLE{Schmaal:153289,
      author       = {Schmaal, Lianne and Pozzi, Elena and C. Ho, Tiffany and van
                      Velzen, Laura S. and Veer, Ilya M. and Opel, Nils and Van
                      Someren, Eus J. W. and Han, Laura K. M. and Aftanas, Lybomir
                      and Aleman, André and Baune, Bernhard T. and Berger, Klaus
                      and Blanken, Tessa F. and Capitão, Liliana and
                      Couvy-Duchesne, Baptiste and R. Cullen, Kathryn and
                      Dannlowski, Udo and Davey, Christopher and Erwin-Grabner,
                      Tracy and Evans, Jennifer and Frodl, Thomas and Fu, Cynthia
                      H. Y. and Godlewska, Beata and Gotlib, Ian H. and
                      Goya-Maldonado, Roberto and Grabe, Hans and Groenewold,
                      Nynke A. and Grotegerd, Dominik and Gruber, Oliver and
                      Gutman, Boris A. and Hall, Geoffrey B. and Harrison, Ben J.
                      and Hatton, Sean N. and Hermesdorf, Marco and Hickie, Ian B.
                      and Hilland, Eva and Irungu, Benson and Jonassen, Rune and
                      Kelly, Sinead and Kircher, Tilo and Klimes-Dougan, Bonnie
                      and Krug, Axel and Landrø, Nils Inge and Lagopoulos, Jim
                      and Leerssen, Jeanne and Li, Meng and Linden, David E. J.
                      and MacMaster, Frank P. and M. McIntosh, Andrew and Mehler,
                      David M. A. and Nenadić, Igor and Penninx, Brenda W. J. H.
                      and Portella, Maria J. and Reneman, Liesbeth and Rentería,
                      Miguel E. and Sacchet, Matthew D. and G. Sämann, Philipp
                      and Schrantee, Anouk and Sim, Kang and Soares, Jair C. and
                      Stein, Dan J. and Tozzi, Leonardo and van Der Wee, Nic J. A.
                      and van Tol, Marie-José and Vermeiren, Robert and
                      Vives-Gilabert, Yolanda and Walter, Henrik and Walter,
                      Martin and Whalley, Heather C. and Wittfeld, Katharina and
                      Whittle, Sarah and Wright, Margaret J. and Yang, Tony T. and
                      Zarate, Carlos and Thomopoulos, Sophia I. and Jahanshad,
                      Neda and Thompson, Paul M. and Veltman, Dick J.},
      title        = {{ENIGMA} {MDD}: seven years of global neuroimaging studies
                      of major depression through worldwide data sharing},
      journal      = {Translational Psychiatry},
      volume       = {10},
      number       = {1},
      issn         = {2158-3188},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {DZNE-2020-01286},
      pages        = {172},
      year         = {2020},
      abstract     = {A key objective in the field of translational psychiatry
                      over the past few decades has been to identify the brain
                      correlates of major depressive disorder (MDD). Identifying
                      measurable indicators of brain processes associated with MDD
                      could facilitate the detection of individuals at risk, and
                      the development of novel treatments, the monitoring of
                      treatment effects, and predicting who might benefit most
                      from treatments that target specific brain mechanisms.
                      However, despite intensive neuroimaging research towards
                      this effort, underpowered studies and a lack of reproducible
                      findings have hindered progress. Here, we discuss the work
                      of the ENIGMA Major Depressive Disorder (MDD) Consortium,
                      which was established to address issues of poor replication,
                      unreliable results, and overestimation of effect sizes in
                      previous studies. The ENIGMA MDD Consortium currently
                      includes data from 45 MDD study cohorts from 14 countries
                      across six continents. The primary aim of ENIGMA MDD is to
                      identify structural and functional brain alterations
                      associated with MDD that can be reliably detected and
                      replicated across cohorts worldwide. A secondary goal is to
                      investigate how demographic, genetic, clinical,
                      psychological, and environmental factors affect these
                      associations. In this review, we summarize findings of the
                      ENIGMA MDD disease working group to date and discuss future
                      directions. We also highlight the challenges and benefits of
                      large-scale data sharing for mental health research.},
      subtyp        = {Review Article},
      keywords     = {Brain: diagnostic imaging / Depression / Depressive
                      Disorder, Major: diagnostic imaging / Humans / Information
                      Dissemination / Neuroimaging},
      cin          = {U Clinical Researchers - Magdeburg / AG Grabe},
      ddc          = {610},
      cid          = {I:(DE-2719)7000000 / I:(DE-2719)5000001},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC7260219},
      pubmed       = {pmid:32472038},
      doi          = {10.1038/s41398-020-0842-6},
      url          = {https://pub.dzne.de/record/153289},
}