000153300 001__ 153300
000153300 005__ 20231206134346.0
000153300 0247_ $$2doi$$a10.1038/s41593-020-0652-4
000153300 0247_ $$2pmid$$apmid:32514139
000153300 0247_ $$2ISSN$$a1097-6256
000153300 0247_ $$2ISSN$$a1546-1726
000153300 0247_ $$2altmetric$$aaltmetric:83634112
000153300 0247_ $$2datacite_doi$$a10.60944/dzne-2020-01297
000153300 037__ $$aDZNE-2020-01297
000153300 041__ $$aEnglish
000153300 082__ $$a610
000153300 1001_ $$0P:(DE-2719)2810397$$aPoll, Stefanie$$b0$$eFirst author
000153300 245__ $$aMemory trace interference impairs recall in a mouse model of Alzheimer's disease.
000153300 260__ $$aNew York, NY$$bNature America$$c2020
000153300 3367_ $$2DRIVER$$aarticle
000153300 3367_ $$2DataCite$$aOutput Types/Journal article
000153300 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1701855795_2030
000153300 3367_ $$2BibTeX$$aARTICLE
000153300 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000153300 3367_ $$00$$2EndNote$$aJournal Article
000153300 520__ $$aIn Alzheimer's disease (AD), hippocampus-dependent memories underlie an extensive decline. The neuronal ensemble encoding a memory, termed engram, is partially recapitulated during memory recall. Artificial activation of an engram can restore memory in a mouse model of early AD, but its fate and the factors that render the engram nonfunctional are yet to be revealed. Here, we used repeated two-photon in vivo imaging to analyze fosGFP transgenic mice (which express enhanced GFP under the Fos promoter) performing a hippocampus-dependent memory task. We found that partial reactivation of the CA1 engram during recall is preserved under AD-like conditions. However, we identified a novelty-like ensemble that interfered with the engram and thus compromised recall. Mimicking a novelty-like ensemble in healthy mice was sufficient to affect memory recall. In turn, reducing the novelty-like signal rescued the recall impairment under AD-like conditions. These findings suggest a novel mechanistic process that contributes to the deterioration of memories in AD.
000153300 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000153300 588__ $$aDataset connected to CrossRef, PubMed,
000153300 650_7 $$2NLM Chemicals$$aAmyloid beta-Protein Precursor
000153300 650_7 $$2NLM Chemicals$$aProto-Oncogene Proteins c-fos
000153300 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000153300 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000153300 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000153300 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: genetics
000153300 650_2 $$2MeSH$$aAmyloid beta-Protein Precursor: metabolism
000153300 650_2 $$2MeSH$$aAnimals
000153300 650_2 $$2MeSH$$aDisease Models, Animal
000153300 650_2 $$2MeSH$$aFemale
000153300 650_2 $$2MeSH$$aHippocampus: physiology
000153300 650_2 $$2MeSH$$aMale
000153300 650_2 $$2MeSH$$aMental Recall: physiology
000153300 650_2 $$2MeSH$$aMice
000153300 650_2 $$2MeSH$$aMice, Transgenic
000153300 650_2 $$2MeSH$$aNeurons: physiology
000153300 650_2 $$2MeSH$$aOptogenetics
000153300 650_2 $$2MeSH$$aProto-Oncogene Proteins c-fos: genetics
000153300 650_2 $$2MeSH$$aProto-Oncogene Proteins c-fos: metabolism
000153300 7001_ $$0P:(DE-2719)2811044$$aMittag, Manuel$$b1
000153300 7001_ $$0P:(DE-2719)2812689$$aMusacchio, Fabrizio$$b2
000153300 7001_ $$0P:(DE-HGF)0$$aJustus, Lena C$$b3
000153300 7001_ $$0P:(DE-HGF)0$$aGiovannetti, Eleonora Ambrad$$b4
000153300 7001_ $$0P:(DE-2719)2810279$$aSteffen, Julia$$b5
000153300 7001_ $$0P:(DE-2719)2662292$$aWagner, Jens$$b6
000153300 7001_ $$aZohren, Lioba$$b7
000153300 7001_ $$aSchoch, Susanne$$b8
000153300 7001_ $$0P:(DE-HGF)0$$aSchmidt, Boris$$b9
000153300 7001_ $$0P:(DE-2719)2810253$$aJackson, Walker S$$b10
000153300 7001_ $$0P:(DE-2719)2289209$$aEhninger, Dan$$b11
000153300 7001_ $$0P:(DE-2719)2679991$$aFuhrmann, Martin$$b12$$eLast author
000153300 773__ $$0PERI:(DE-600)1494955-6$$a10.1038/s41593-020-0652-4$$gVol. 23, no. 8, p. 952 - 958$$n8$$p952 - 958$$tNature neuroscience$$v23$$x1546-1726$$y2020
000153300 8564_ $$uhttps://pub.dzne.de/record/153300/files/DZNE-2020-01297.pdf$$yPublished on 2020-06-08. Available in OpenAccess from 2021-06-08.$$zStatID:(DE-HGF)0510
000153300 8564_ $$uhttps://pub.dzne.de/record/153300/files/DZNE-2020-01297.pdf?subformat=pdfa$$xpdfa$$yPublished on 2020-06-08. Available in OpenAccess from 2021-06-08.$$zStatID:(DE-HGF)0510
000153300 909CO $$ooai:pub.dzne.de:153300$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000153300 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-09-30
000153300 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)0530$$2StatID$$aEmbargoed OpenAccess
000153300 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT NEUROSCI : 2021$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-09-30
000153300 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000153300 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)0514$$2StatID$$aGreen Open Access
000153300 915__ $$0StatID:(DE-HGF)9925$$2StatID$$aIF >= 25$$bNAT NEUROSCI : 2021$$d2022-11-12
000153300 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-09-30
000153300 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2022-11-12$$wger
000153300 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-12
000153300 9141_ $$y2020
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810397$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811044$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812689$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b2$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-HGF)0$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-HGF)0$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810279$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2662292$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810253$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b10$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2289209$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b11$$kDZNE
000153300 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2679991$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000153300 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000153300 9132_ $$0G:(DE-HGF)POF4-899$$1G:(DE-HGF)POF4-890$$2G:(DE-HGF)POF4-800$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bProgrammungebundene Forschung$$lohne Programm$$vohne Topic$$x0
000153300 9201_ $$0I:(DE-2719)1011004$$kAG Fuhrmann$$lNeuroimmunology and Imaging$$x0
000153300 9201_ $$0I:(DE-2719)1013019$$kAG Jackson$$lSelective Vulnerability of Neurodegenerative Diseases$$x1
000153300 9201_ $$0I:(DE-2719)1013005$$kAG Ehninger$$lTranslational Biogerontology$$x2
000153300 980__ $$ajournal
000153300 980__ $$aVDB
000153300 980__ $$aI:(DE-2719)1011004
000153300 980__ $$aI:(DE-2719)1013019
000153300 980__ $$aI:(DE-2719)1013005
000153300 980__ $$aUNRESTRICTED
000153300 9801_ $$aFullTexts