Home > Publications Database > Memory trace interference impairs recall in a mouse model of Alzheimer's disease. > print

001     153300
005     20231206134346.0
024 7 _ |2 doi
|a 10.1038/s41593-020-0652-4
024 7 _ |2 pmid
|a pmid:32514139
024 7 _ |2 ISSN
|a 1097-6256
024 7 _ |2 ISSN
|a 1546-1726
024 7 _ |2 altmetric
|a altmetric:83634112
024 7 _ |2 datacite_doi
|a 10.60944/dzne-2020-01297
037 _ _ |a DZNE-2020-01297
041 _ _ |a English
082 _ _ |a 610
100 1 _ |0 P:(DE-2719)2810397
|a Poll, Stefanie
|b 0
|e First author
245 _ _ |a Memory trace interference impairs recall in a mouse model of Alzheimer's disease.
260 _ _ |a New York, NY
|b Nature America
|c 2020
336 7 _ |2 DRIVER
|a article
336 7 _ |2 DataCite
|a Output Types/Journal article
336 7 _ |0 PUB:(DE-HGF)16
|2 PUB:(DE-HGF)
|a Journal Article
|b journal
|m journal
|s 1701855795_2030
336 7 _ |2 BibTeX
|a ARTICLE
336 7 _ |2 ORCID
|a JOURNAL_ARTICLE
336 7 _ |0 0
|2 EndNote
|a Journal Article
520 _ _ |a In Alzheimer's disease (AD), hippocampus-dependent memories underlie an extensive decline. The neuronal ensemble encoding a memory, termed engram, is partially recapitulated during memory recall. Artificial activation of an engram can restore memory in a mouse model of early AD, but its fate and the factors that render the engram nonfunctional are yet to be revealed. Here, we used repeated two-photon in vivo imaging to analyze fosGFP transgenic mice (which express enhanced GFP under the Fos promoter) performing a hippocampus-dependent memory task. We found that partial reactivation of the CA1 engram during recall is preserved under AD-like conditions. However, we identified a novelty-like ensemble that interfered with the engram and thus compromised recall. Mimicking a novelty-like ensemble in healthy mice was sufficient to affect memory recall. In turn, reducing the novelty-like signal rescued the recall impairment under AD-like conditions. These findings suggest a novel mechanistic process that contributes to the deterioration of memories in AD.
536 _ _ |0 G:(DE-HGF)POF3-342
|a 342 - Disease Mechanisms and Model Systems (POF3-342)
|c POF3-342
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |2 NLM Chemicals
|a Amyloid beta-Protein Precursor
650 _ 7 |2 NLM Chemicals
|a Proto-Oncogene Proteins c-fos
650 _ 2 |2 MeSH
|a Alzheimer Disease: genetics
650 _ 2 |2 MeSH
|a Alzheimer Disease: metabolism
650 _ 2 |2 MeSH
|a Alzheimer Disease: physiopathology
650 _ 2 |2 MeSH
|a Amyloid beta-Protein Precursor: genetics
650 _ 2 |2 MeSH
|a Amyloid beta-Protein Precursor: metabolism
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Disease Models, Animal
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Hippocampus: physiology
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Mental Recall: physiology
650 _ 2 |2 MeSH
|a Mice
650 _ 2 |2 MeSH
|a Mice, Transgenic
650 _ 2 |2 MeSH
|a Neurons: physiology
650 _ 2 |2 MeSH
|a Optogenetics
650 _ 2 |2 MeSH
|a Proto-Oncogene Proteins c-fos: genetics
650 _ 2 |2 MeSH
|a Proto-Oncogene Proteins c-fos: metabolism
700 1 _ |0 P:(DE-2719)2811044
|a Mittag, Manuel
|b 1
700 1 _ |0 P:(DE-2719)2812689
|a Musacchio, Fabrizio
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Justus, Lena C
|b 3
700 1 _ |0 P:(DE-HGF)0
|a Giovannetti, Eleonora Ambrad
|b 4
700 1 _ |0 P:(DE-2719)2810279
|a Steffen, Julia
|b 5
700 1 _ |0 P:(DE-2719)2662292
|a Wagner, Jens
|b 6
700 1 _ |a Zohren, Lioba
|b 7
700 1 _ |a Schoch, Susanne
|b 8
700 1 _ |0 P:(DE-HGF)0
|a Schmidt, Boris
|b 9
700 1 _ |0 P:(DE-2719)2810253
|a Jackson, Walker S
|b 10
700 1 _ |0 P:(DE-2719)2289209
|a Ehninger, Dan
|b 11
700 1 _ |0 P:(DE-2719)2679991
|a Fuhrmann, Martin
|b 12
|e Last author
773 _ _ |0 PERI:(DE-600)1494955-6
|a 10.1038/s41593-020-0652-4
|g Vol. 23, no. 8, p. 952 - 958
|n 8
|p 952 - 958
|t Nature neuroscience
|v 23
|x 1546-1726
|y 2020
856 4 _ |u https://pub.dzne.de/record/153300/files/DZNE-2020-01297.pdf
|y Published on 2020-06-08. Available in OpenAccess from 2021-06-08.
|z StatID:(DE-HGF)0510
856 4 _ |u https://pub.dzne.de/record/153300/files/DZNE-2020-01297.pdf?subformat=pdfa
|x pdfa
|y Published on 2020-06-08. Available in OpenAccess from 2021-06-08.
|z StatID:(DE-HGF)0510
909 C O |o oai:pub.dzne.de:153300
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2810397
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 0
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2811044
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 1
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2812689
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 2
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-HGF)0
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 3
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-HGF)0
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 4
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2810279
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 5
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2662292
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 6
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2810253
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 10
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2289209
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 11
|k DZNE
910 1 _ |0 I:(DE-588)1065079516
|6 P:(DE-2719)2679991
|a Deutsches Zentrum für Neurodegenerative Erkrankungen
|b 12
|k DZNE
913 1 _ |0 G:(DE-HGF)POF3-342
|1 G:(DE-HGF)POF3-340
|2 G:(DE-HGF)POF3-300
|3 G:(DE-HGF)POF3
|4 G:(DE-HGF)POF
|a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|v Disease Mechanisms and Model Systems
|x 0
913 2 _ |0 G:(DE-HGF)POF4-899
|1 G:(DE-HGF)POF4-890
|2 G:(DE-HGF)POF4-800
|3 G:(DE-HGF)POF4
|4 G:(DE-HGF)POF
|a DE-HGF
|b Programmungebundene Forschung
|l ohne Programm
|v ohne Topic
|x 0
914 1 _ |y 2020
915 _ _ |0 StatID:(DE-HGF)0200
|2 StatID
|a DBCoverage
|b SCOPUS
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)0300
|2 StatID
|a DBCoverage
|b Medline
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)1050
|2 StatID
|a DBCoverage
|b BIOSIS Previews
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)1190
|2 StatID
|a DBCoverage
|b Biological Abstracts
|d 2020-09-30
915 _ _ |0 StatID:(DE-HGF)0600
|2 StatID
|a DBCoverage
|b Ebsco Academic Search
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)0530
|2 StatID
|a Embargoed OpenAccess
915 _ _ |0 StatID:(DE-HGF)0100
|2 StatID
|a JCR
|b NAT NEUROSCI : 2021
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)0113
|2 StatID
|a WoS
|b Science Citation Index Expanded
|d 2020-09-30
915 _ _ |0 StatID:(DE-HGF)1030
|2 StatID
|a DBCoverage
|b Current Contents - Life Sciences
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)0150
|2 StatID
|a DBCoverage
|b Web of Science Core Collection
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)0510
|2 StatID
|a OpenAccess
915 _ _ |0 StatID:(DE-HGF)0030
|2 StatID
|a Peer Review
|b ASC
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)0514
|2 StatID
|a Green Open Access
915 _ _ |0 StatID:(DE-HGF)9925
|2 StatID
|a IF >= 25
|b NAT NEUROSCI : 2021
|d 2022-11-12
915 _ _ |0 StatID:(DE-HGF)0160
|2 StatID
|a DBCoverage
|b Essential Science Indicators
|d 2020-09-30
915 _ _ |0 StatID:(DE-HGF)0420
|2 StatID
|a Nationallizenz
|d 2022-11-12
|w ger
915 _ _ |0 StatID:(DE-HGF)0199
|2 StatID
|a DBCoverage
|b Clarivate Analytics Master Journal List
|d 2022-11-12
920 1 _ |0 I:(DE-2719)1011004
|k AG Fuhrmann
|l Neuroimmunology and Imaging
|x 0
920 1 _ |0 I:(DE-2719)1013019
|k AG Jackson
|l Selective Vulnerability of Neurodegenerative Diseases
|x 1
920 1 _ |0 I:(DE-2719)1013005
|k AG Ehninger
|l Translational Biogerontology
|x 2
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-2719)1011004
980 _ _ |a I:(DE-2719)1013019
980 _ _ |a I:(DE-2719)1013005
980 _ _ |a UNRESTRICTED
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21