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@ARTICLE{Bouter:153323,
      author       = {Bouter, Caroline and Hansen, Niels and Timäus, Charles and
                      Wiltfang, Jens and Lange, Claudia},
      title        = {{C}ase {R}eport: {T}he {R}ole of {N}europsychological
                      {A}ssessment and {I}maging {B}iomarkers in the {E}arly
                      {D}iagnosis of {L}ewy {B}ody {D}ementia in a {P}atient
                      {W}ith {M}ajor {D}epression and {P}rolonged {A}lcohol and
                      {B}enzodiazepine {D}ependence},
      journal      = {Frontiers in psychiatry},
      volume       = {11},
      issn         = {1664-0640},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2020-01320},
      pages        = {684},
      year         = {2020},
      abstract     = {Dementia with Lewy bodies (DLB) is the second most common
                      form of dementia and is assumed to be often under- or
                      misdiagnosed, especially in early stages. Here we present a
                      complex case of probable DLB with major depression and
                      alcohol and benzodiazepine dependence in which DLB was ruled
                      out initially. This case highlights the challenging
                      diagnostic workup of DLB patients. Core clinical features
                      can be missing and indicative biomarkers can be negative,
                      especially in early stages of the disease. Initially,
                      Fluorodeoxyglucose positron emission tomography as well as
                      neuropsychological assessment were suspicious for a possible
                      DLB diagnosis in our patient while core clinical criteria
                      were missing and the indicative biomarker 123I-FP-CIT SPECT
                      was negative. Follow up was performed two years later and
                      the patients showed several core and supportive clinical
                      features of DLB and 123I-FP-CIT SPECT showed a pathological
                      pattern. Extensive neuropsychological assessment in
                      combination with PET imaging might provide crucial evidence
                      for DLB even in early stages. If neuropsychology and PET
                      imaging point to an early DLB diagnosis careful follow-up
                      should be performed as core symptoms and indicative
                      biomarkers might appear in later stages of the disease.},
      cin          = {AG Wiltfang / U T4 Researchers - Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)1410006 / I:(DE-2719)7000008},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 345
                      - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32760301},
      pmc          = {pmc:PMC7373778},
      doi          = {10.3389/fpsyt.2020.00684},
      url          = {https://pub.dzne.de/record/153323},
}