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000153351 0247_ $$2doi$$a10.1126/sciimmunol.aba4163
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000153351 041__ $$aEnglish
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000153351 1001_ $$00000-0003-2739-5578$$aKrebs, Christian F.$$b0$$eCorresponding author
000153351 245__ $$aPathogen-induced tissue-resident memory T H 17 (T RM 17) cells amplify autoimmune kidney disease
000153351 260__ $$aWashington, DC$$bAAAS$$c2020
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000153351 520__ $$aAlthough it is well established that microbial infections predispose to autoimmune diseases, the underlying mechanisms remain poorly understood. After infection, tissue-resident memory T (TRM) cells persist in peripheral organs and provide immune protection against reinfection. However, whether TRM cells participate in responses unrelated to the primary infection, such as autoimmune inflammation, is unknown. By using high-dimensional single-cell analysis, we identified CD4+ TRM cells with a TH17 signature (termed TRM17 cells) in kidneys of patients with ANCA-associated glomerulonephritis. Experimental models demonstrated that renal TRM17 cells were induced by pathogens infecting the kidney, such as Staphylococcus aureus, Candida albicans, and uropathogenic Escherichia coli, and persisted after the clearance of infections. Upon induction of experimental glomerulonephritis, these kidney TRM17 cells rapidly responded to local proinflammatory cytokines by producing IL-17A and thereby exacerbate renal pathology. Thus, our data show that pathogen-induced TRM17 cells have a previously unrecognized function in aggravating autoimmune disease.
000153351 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000153351 650_2 $$2MeSH$$aAnimals
000153351 650_2 $$2MeSH$$aAntibodies, Antineutrophil Cytoplasmic: immunology
000153351 650_2 $$2MeSH$$aAutoimmune Diseases: immunology
000153351 650_2 $$2MeSH$$aAutoimmune Diseases: microbiology
000153351 650_2 $$2MeSH$$aBacterial Infections: immunology
000153351 650_2 $$2MeSH$$aCD4-Positive T-Lymphocytes: immunology
000153351 650_2 $$2MeSH$$aCandida albicans
000153351 650_2 $$2MeSH$$aCandidiasis: immunology
000153351 650_2 $$2MeSH$$aGlomerulonephritis: immunology
000153351 650_2 $$2MeSH$$aGlomerulonephritis: microbiology
000153351 650_2 $$2MeSH$$aHumans
000153351 650_2 $$2MeSH$$aImmunologic Memory
000153351 650_2 $$2MeSH$$aKidney: immunology
000153351 650_2 $$2MeSH$$aMale
000153351 650_2 $$2MeSH$$aMice, Inbred DBA
000153351 650_2 $$2MeSH$$aMice, Transgenic
000153351 650_2 $$2MeSH$$aT-Lymphocyte Subsets: immunology
000153351 7001_ $$00000-0002-2225-2001$$aReimers, Daniel$$b1
000153351 7001_ $$00000-0003-2632-7530$$aZhao, Yu$$b2
000153351 7001_ $$aPaust, Hans-Joachim$$b3
000153351 7001_ $$00000-0002-6946-4757$$aBartsch, Patricia$$b4
000153351 7001_ $$00000-0001-8102-8010$$aNuñez, Sarah$$b5
000153351 7001_ $$00000-0003-2268-4733$$aRosemblatt, Mariana V.$$b6
000153351 7001_ $$aHellmig, Malte$$b7
000153351 7001_ $$00000-0003-0933-6152$$aKilian, Christoph$$b8
000153351 7001_ $$aBorchers, Alina$$b9
000153351 7001_ $$00000-0003-4158-1772$$aEnk, Leon U. B.$$b10
000153351 7001_ $$00000-0002-6141-718X$$aZinke, Michael$$b11
000153351 7001_ $$00000-0002-7598-2964$$aBecker, Martina$$b12
000153351 7001_ $$aSchmid, Joanna$$b13
000153351 7001_ $$00000-0003-3959-358X$$aKlinge, Stefanie$$b14
000153351 7001_ $$aWong, Milagros N.$$b15
000153351 7001_ $$00000-0002-7735-5462$$aPuelles, Victor G.$$b16
000153351 7001_ $$00000-0002-3892-4255$$aSchmidt, Constantin$$b17
000153351 7001_ $$00000-0003-3338-5536$$aBertram, Tabea$$b18
000153351 7001_ $$00000-0001-5262-0904$$aStumpf, Natascha$$b19
000153351 7001_ $$aHoxha, Elion$$b20
000153351 7001_ $$aMeyer-Schwesinger, Catherine$$b21
000153351 7001_ $$aLindenmeyer, Maja T.$$b22
000153351 7001_ $$00000-0002-7201-5805$$aCohen, Clemens D.$$b23
000153351 7001_ $$aRink, Michael$$b24
000153351 7001_ $$00000-0002-6620-2401$$aKurts, Christian$$b25
000153351 7001_ $$00000-0001-6374-4910$$aFranzenburg, Sören$$b26
000153351 7001_ $$00000-0003-1730-6674$$aKoch-Nolte, Friedrich$$b27
000153351 7001_ $$aTurner, Jan-Eric$$b28
000153351 7001_ $$00000-0002-6562-5197$$aRiedel, Jan-Hendrik$$b29
000153351 7001_ $$00000-0001-9325-8227$$aHuber, Samuel$$b30
000153351 7001_ $$aGagliani, Nicola$$b31
000153351 7001_ $$00000-0001-7175-5062$$aHuber, Tobias B.$$b32
000153351 7001_ $$00000-0003-4053-1474$$aWiech, Thorsten$$b33
000153351 7001_ $$aRohde, Holger$$b34
000153351 7001_ $$00000-0001-9318-343X$$aBono, Maria Rosa$$b35
000153351 7001_ $$0P:(DE-2719)2810547$$aBonn, Stefan$$b36$$udzne
000153351 7001_ $$aPanzer, Ulf$$b37
000153351 7001_ $$00000-0001-6166-4191$$aMittrücker, Hans-Willi$$b38$$eCorresponding author
000153351 773__ $$0PERI:(DE-600)2862556-0$$a10.1126/sciimmunol.aba4163$$gVol. 5, no. 50, p. eaba4163 -$$n50$$peaba4163$$tScience immunology$$v5$$x2470-9468$$y2020
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