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000153359 0247_ $$2doi$$a10.1016/j.clinph.2020.03.026
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000153359 0247_ $$2ISSN$$a1388-2457
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000153359 037__ $$aDZNE-2020-01356
000153359 041__ $$aEnglish
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000153359 1001_ $$0P:(DE-2719)2812631$$aSchreiber, Stefanie$$b0$$eFirst author$$udzne
000153359 245__ $$aPeripheral nerve imaging in amyotrophic lateral sclerosis
000153359 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2020
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000153359 520__ $$aWe systematically identified and reviewed 29 studies of peripheral nerve ultrasound or magnetic resonance imaging (MRN) in amyotrophic lateral sclerosis (ALS). The majority of the ultrasound studies reported smaller nerves and nerve roots in ALS compared to healthy controls, but there was a large overlap of the cross-sectional nerve area between ALS and controls. Most of the MRN studies confirmed nerve abnormalities demonstrating slight T2 hyperintensities and, sometimes, mild enlargement of more proximal nerve segments (plexus, roots) in ALS. The size of the proximal nerve segments, i.e. nerve roots, is thus somewhat incongruent between nerve ultrasound and MRN in ALS. Peripheral nerve ultrasound has the potential to differentiate between ALS and multifocal motor neuropathy (MMN) in that patients with MMN have significantly larger nerves. Conversely, there is an overlap of MRN abnormalities in ALS and MMN, restricting the techniques’ utility in the clinical setting. A subgroup of patients with ALS seems to reveal a sonographic nerve pattern suggesting peripheral nerve inflammation. In the future, combined imaging with nerve ultrasound and MRN assessing parameters such as blood flow or textural markers may aid in the understanding of the deep nerve microstructure down to the fascicle level, and thus, in the classification of the nerve state as more degenerative or more inflammatory in ALS. This systematic review provides evidence that nerve imaging abnormalities are common in ALS.
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000153359 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: diagnostic imaging
000153359 650_2 $$2MeSH$$aHumans
000153359 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000153359 650_2 $$2MeSH$$aPeripheral Nerves: diagnostic imaging
000153359 650_2 $$2MeSH$$aUltrasonography: methods
000153359 7001_ $$0P:(DE-2719)2000035$$aVielhaber, Stefan$$b1$$udzne
000153359 7001_ $$0P:(DE-2719)9000986$$aSchreiber, Frank$$b2$$udzne
000153359 7001_ $$aCartwright, Michael S.$$b3
000153359 773__ $$0PERI:(DE-600)1499934-1$$a10.1016/j.clinph.2020.03.026$$gVol. 131, no. 9, p. 2315 - 2326$$n9$$p2315 - 2326$$tClinical neurophysiology$$v131$$x1388-2457$$y2020
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