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@ARTICLE{Schreiber:153359,
      author       = {Schreiber, Stefanie and Vielhaber, Stefan and Schreiber,
                      Frank and Cartwright, Michael S.},
      title        = {{P}eripheral nerve imaging in amyotrophic lateral
                      sclerosis},
      journal      = {Clinical neurophysiology},
      volume       = {131},
      number       = {9},
      issn         = {1388-2457},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-01356},
      pages        = {2315 - 2326},
      year         = {2020},
      abstract     = {We systematically identified and reviewed 29 studies of
                      peripheral nerve ultrasound or magnetic resonance imaging
                      (MRN) in amyotrophic lateral sclerosis (ALS). The majority
                      of the ultrasound studies reported smaller nerves and nerve
                      roots in ALS compared to healthy controls, but there was a
                      large overlap of the cross-sectional nerve area between ALS
                      and controls. Most of the MRN studies confirmed nerve
                      abnormalities demonstrating slight T2 hyperintensities and,
                      sometimes, mild enlargement of more proximal nerve segments
                      (plexus, roots) in ALS. The size of the proximal nerve
                      segments, i.e. nerve roots, is thus somewhat incongruent
                      between nerve ultrasound and MRN in ALS. Peripheral nerve
                      ultrasound has the potential to differentiate between ALS
                      and multifocal motor neuropathy (MMN) in that patients with
                      MMN have significantly larger nerves. Conversely, there is
                      an overlap of MRN abnormalities in ALS and MMN, restricting
                      the techniques’ utility in the clinical setting. A
                      subgroup of patients with ALS seems to reveal a sonographic
                      nerve pattern suggesting peripheral nerve inflammation. In
                      the future, combined imaging with nerve ultrasound and MRN
                      assessing parameters such as blood flow or textural markers
                      may aid in the understanding of the deep nerve
                      microstructure down to the fascicle level, and thus, in the
                      classification of the nerve state as more degenerative or
                      more inflammatory in ALS. This systematic review provides
                      evidence that nerve imaging abnormalities are common in
                      ALS.},
      subtyp        = {Review Article},
      keywords     = {Amyotrophic Lateral Sclerosis: diagnostic imaging / Humans
                      / Magnetic Resonance Imaging: methods / Peripheral Nerves:
                      diagnostic imaging / Ultrasonography: methods},
      cin          = {AG Reymann / U Clinical Researchers - Magdeburg / AG
                      Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)1310005 / I:(DE-2719)7000000 /
                      I:(DE-2719)5000006},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32340815},
      doi          = {10.1016/j.clinph.2020.03.026},
      url          = {https://pub.dzne.de/record/153359},
}