%0 Journal Article
%A Neu, Axel
%A Hornig, Sönke
%A Sasani, Ali
%A Isbrandt, Dirk
%A Gerloff, Christian
%A Tsikas, Dimitris
%A Schwedhelm, Edzard
%A Choe, Chi-Un
%T Creatine, guanidinoacetate and homoarginine in statin-induced myopathy.
%J Amino acids
%V 52
%N 6-7
%@ 1438-2199
%C Wien [u.a.]
%I Springer
%M DZNE-2020-01371
%P 1067 - 1069
%D 2020
%X Our study evaluated the effect of creatine and homoarginine in AGAT- and GAMT-deficient mice after simvastatin exposure. Balestrino and Adriano suggest that guanidinoacetate might explain the difference between AGAT- and GAMT-deficient mice in simvastatin-induced myopathy. We agree with Balestrino and Adriano that our data shows that (1) creatine possesses a protective potential to ameliorate statin-induced myopathy in humans and mice and (2) homoarginine did not reveal a beneficial effect in statin-induced myopathy. Third, we agree that guanidinoacetate can be phosphorylated and partially compensate for phosphocreatine. In our study, simvastatin-induced damage showed a trend to be less pronounced in GAMT-deficient mice compared with wildtype mice. Therefore, (phospo) guanidinoacetate cannot completely explain the milder phenotype of GAMT-deficient mice, but we agree that it might contribute to ameliorate statin-induced myopathy in GAMT-deficient mice compared with AGAT-deficient mice. Finally, we agree with Balestino and Adriano that AGAT metabolites should further be evaluated as potential treatments in statin-induced myopathy.
%K Amidinotransferases: deficiency
%K Amino Acid Metabolism, Inborn Errors
%K Animals
%K Creatine: metabolism
%K Creatine: pharmacology
%K Developmental Disabilities
%K Glycine: analogs & derivatives
%K Glycine: metabolism
%K Guanidinoacetate N-Methyltransferase: deficiency
%K Homoarginine: metabolism
%K Hydroxymethylglutaryl-CoA Reductase Inhibitors
%K Intellectual Disability
%K Mice
%K Muscular Diseases: chemically induced
%K Muscular Diseases: metabolism
%K Phosphocreatine: metabolism
%K Speech Disorders
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32594255
%2 pmc:PMC7406479
%R 10.1007/s00726-020-02865-w
%U https://pub.dzne.de/record/153374