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000153374 0247_ $$2ISSN$$a1438-2199
000153374 037__ $$aDZNE-2020-01371
000153374 041__ $$aEnglish
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000153374 1001_ $$aNeu, Axel$$b0
000153374 245__ $$aCreatine, guanidinoacetate and homoarginine in statin-induced myopathy.
000153374 260__ $$aWien [u.a.]$$bSpringer$$c2020
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000153374 520__ $$aOur study evaluated the effect of creatine and homoarginine in AGAT- and GAMT-deficient mice after simvastatin exposure. Balestrino and Adriano suggest that guanidinoacetate might explain the difference between AGAT- and GAMT-deficient mice in simvastatin-induced myopathy. We agree with Balestrino and Adriano that our data shows that (1) creatine possesses a protective potential to ameliorate statin-induced myopathy in humans and mice and (2) homoarginine did not reveal a beneficial effect in statin-induced myopathy. Third, we agree that guanidinoacetate can be phosphorylated and partially compensate for phosphocreatine. In our study, simvastatin-induced damage showed a trend to be less pronounced in GAMT-deficient mice compared with wildtype mice. Therefore, (phospo) guanidinoacetate cannot completely explain the milder phenotype of GAMT-deficient mice, but we agree that it might contribute to ameliorate statin-induced myopathy in GAMT-deficient mice compared with AGAT-deficient mice. Finally, we agree with Balestino and Adriano that AGAT metabolites should further be evaluated as potential treatments in statin-induced myopathy.
000153374 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
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000153374 650_2 $$2MeSH$$aAmidinotransferases: deficiency
000153374 650_2 $$2MeSH$$aAmino Acid Metabolism, Inborn Errors
000153374 650_2 $$2MeSH$$aAnimals
000153374 650_2 $$2MeSH$$aCreatine: metabolism
000153374 650_2 $$2MeSH$$aCreatine: pharmacology
000153374 650_2 $$2MeSH$$aDevelopmental Disabilities
000153374 650_2 $$2MeSH$$aGlycine: analogs & derivatives
000153374 650_2 $$2MeSH$$aGlycine: metabolism
000153374 650_2 $$2MeSH$$aGuanidinoacetate N-Methyltransferase: deficiency
000153374 650_2 $$2MeSH$$aHomoarginine: metabolism
000153374 650_2 $$2MeSH$$aHydroxymethylglutaryl-CoA Reductase Inhibitors
000153374 650_2 $$2MeSH$$aIntellectual Disability
000153374 650_2 $$2MeSH$$aMice
000153374 650_2 $$2MeSH$$aMuscular Diseases: chemically induced
000153374 650_2 $$2MeSH$$aMuscular Diseases: metabolism
000153374 650_2 $$2MeSH$$aPhosphocreatine: metabolism
000153374 650_2 $$2MeSH$$aSpeech Disorders
000153374 7001_ $$aHornig, Sönke$$b1
000153374 7001_ $$aSasani, Ali$$b2
000153374 7001_ $$0P:(DE-2719)2810976$$aIsbrandt, Dirk$$b3$$udzne
000153374 7001_ $$aGerloff, Christian$$b4
000153374 7001_ $$aTsikas, Dimitris$$b5
000153374 7001_ $$aSchwedhelm, Edzard$$b6
000153374 7001_ $$0P:(DE-HGF)0$$aChoe, Chi-Un$$b7$$eCorresponding author
000153374 773__ $$0PERI:(DE-600)1480643-5$$a10.1007/s00726-020-02865-w$$gVol. 52, no. 6-7, p. 1067 - 1069$$n6-7$$p1067 - 1069$$tAmino acids$$v52$$x1438-2199$$y2020
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