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@ARTICLE{Dietachmayr:153412,
      author       = {Dietachmayr, Michael and Rathakrishnan, Abirami and
                      Karpiuk, Oleksandra and von Zweydorf, Felix and Engleitner,
                      Thomas and Fernández-Sáiz, Vanesa and Schenk, Petra and
                      Ueffing, Marius and Rad, Roland and Eilers, Martin and
                      Gloeckner, Christian Johannes and Clemm von Hohenberg,
                      Katharina and Bassermann, Florian},
      title        = {{A}ntagonistic activities of {CDC}14{B} and {CDK}1 on
                      {USP}9{X} regulate {WT}1-dependent mitotic transcription and
                      survival.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2020-01409},
      pages        = {1268},
      year         = {2020},
      abstract     = {Regulation of mitosis secures cellular integrity and its
                      failure critically contributes to the development,
                      maintenance, and treatment resistance of cancer. In yeast,
                      the dual phosphatase Cdc14 controls mitotic progression by
                      antagonizing Cdk1-mediated protein phosphorylation. By
                      contrast, specific mitotic functions of the mammalian Cdc14
                      orthologue CDC14B have remained largely elusive. Here, we
                      find that CDC14B antagonizes CDK1-mediated activating
                      mitotic phosphorylation of the deubiquitinase USP9X at
                      serine residue 2563, which we show to be essential for USP9X
                      to mediate mitotic survival. Starting from an unbiased
                      proteome-wide screening approach, we specify Wilms' tumor
                      protein 1 (WT1) as the relevant substrate that becomes
                      deubiquitylated and stabilized by serine 2563-phosphorylated
                      USP9X in mitosis. We further demonstrate that WT1 functions
                      as a mitotic transcription factor and specify CXCL8/IL-8 as
                      a target gene of WT1 that conveys mitotic survival.
                      Together, we describe a ubiquitin-dependent signaling
                      pathway that directs a mitosis-specific transcription
                      program to regulate mitotic survival.},
      keywords     = {A549 Cells / Apoptosis / CDC2 Protein Kinase: antagonists
                      $\&$ inhibitors / Dual-Specificity Phosphatases: antagonists
                      $\&$ inhibitors / Gene Knockdown Techniques / HEK293 Cells /
                      HeLa Cells / Humans / Interleukin-8: metabolism / Mitosis:
                      physiology / Phosphorylation / Transcription Factors /
                      Ubiquitin Thiolesterase: drug effects / Ubiquitin
                      Thiolesterase: genetics / Ubiquitin Thiolesterase:
                      metabolism / WT1 Proteins: genetics / WT1 Proteins:
                      metabolism / CXCL8 protein, human (NLM Chemicals) /
                      Interleukin-8 (NLM Chemicals) / Transcription Factors (NLM
                      Chemicals) / USP9X protein, human (NLM Chemicals) / WT1
                      Proteins (NLM Chemicals) / WT1 protein, human (NLM
                      Chemicals) / CDC2 Protein Kinase (NLM Chemicals) / CDK1
                      protein, human (NLM Chemicals) / CDC14B protein, human (NLM
                      Chemicals) / Dual-Specificity Phosphatases (NLM Chemicals) /
                      Ubiquitin Thiolesterase (NLM Chemicals)},
      cin          = {AG Gloeckner},
      ddc          = {500},
      cid          = {I:(DE-2719)1210007},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32152317},
      pmc          = {pmc:PMC7063047},
      doi          = {10.1038/s41467-020-15059-5},
      url          = {https://pub.dzne.de/record/153412},
}