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@ARTICLE{Weselek:153416,
      author       = {Weselek, Grit and Keiner, Silke and Fauser, Mareike and
                      Wagenführ, Lisa and Müller, Julia and Kaltschmidt, Barbara
                      and Brandt, Moritz D and Gerlach, Manfred and Redecker,
                      Christoph and Hermann, Andreas and Storch, Alexander},
      title        = {{N}orepinephrine is a negative regulator of the adult
                      periventricular neural stem cell niche.},
      journal      = {Stem cells},
      volume       = {38},
      number       = {9},
      issn         = {1066-5099},
      address      = {Hoboken, NJ},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2020-01413},
      pages        = {1188–1201},
      year         = {2020},
      abstract     = {The limited proliferative capacity of neuroprogenitor cells
                      (NPCs) within the periventricular germinal niches (PGNs)
                      located caudal of the subventricular zone (SVZ) of the
                      lateral ventricles together with their high proliferation
                      capacity after isolation strongly implicates cell-extrinsic
                      humoral factors restricting NPC proliferation in the
                      hypothalamic and midbrain PGNs. We comparatively examined
                      the effects of norepinephrine (NE) as an endogenous
                      candidate regulator of PGN neurogenesis in the SVZ as well
                      as the periventricular hypothalamus and the periaqueductal
                      midbrain. Histological and neurochemical analyses revealed
                      that the pattern of NE innervation of the adult PGNs is
                      inversely associated with their in vivo NPC proliferation
                      capacity with low NE levels coupled to high NPC
                      proliferation in the SVZ but high NE levels coupled to low
                      NPC proliferation in hypothalamic and midbrain PGNs.
                      Intraventricular infusion of NE decreased NPC proliferation
                      and neurogenesis in the SVZ-olfactory bulb system, while
                      pharmacological NE inhibition increased NPC proliferation
                      and early neurogenesis events in the caudal PGNs. Neurotoxic
                      ablation of NE neurons using the Dsp4-fluoxetine protocol
                      confirmed its inhibitory effects on NPC proliferation.
                      Contrarily, NE depletion largely impairs NPC proliferation
                      within the hippocampus in the same animals. Our data
                      indicate that norepinephrine has opposite effects on the two
                      fundamental neurogenic niches of the adult brain with
                      norepinephrine being a negative regulator of adult
                      periventricular neurogenesis. This knowledge might
                      ultimately lead to new therapeutic approaches to influence
                      neurogenesis in hypothalamus-related metabolic diseases or
                      to stimulate endogenous regenerative potential in
                      neurodegenerative processes such as Parkinson's disease.},
      keywords     = {Animals / Cell Proliferation: drug effects / Hippocampus:
                      cytology / Lateral Ventricles: cytology / Mesencephalon:
                      cytology / Mice, Inbred C57BL / Neural Stem Cells: cytology
                      / Neural Stem Cells: drug effects / Neurogenesis: drug
                      effects / Norepinephrine: pharmacology / Olfactory Bulb:
                      cytology / Phenotype / Receptors, Adrenergic, beta:
                      metabolism / Signal Transduction: drug effects / Stem Cell
                      Niche},
      cin          = {AG Storch},
      ddc          = {610},
      cid          = {I:(DE-2719)5000014},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32473039},
      doi          = {10.1002/stem.3232},
      url          = {https://pub.dzne.de/record/153416},
}