TY  - JOUR
AU  - Vogt, Susanne
AU  - Schreiber, Stefanie
AU  - Pfau, Giselher
AU  - Kollewe, Katja
AU  - Heinze, Hans-Jochen
AU  - Dengler, Reinhard
AU  - Petri, Susanne
AU  - Vielhaber, Stefan
AU  - Brinkers, Michael
TI  - Dyspnea as a Fatigue-Promoting Factor in ALS and the Role of Objective Indicators of Respiratory Impairment
JO  - Journal of pain and symptom management
VL  - 60
IS  - 2
SN  - 0885-3924
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-01432
SP  - 430 - 438.e1
PY  - 2020
AB  - ContextThere is no evidence-based treatment for fatigue in amyotrophic lateral sclerosis (ALS), and identification of treatable causes determines management strategies. Although dyspnea is a key symptom of ALS and effectively treatable, it has not been sufficiently investigated whether dyspnea may be a fatigue-promoting factor.ObjectivesTo determine the level of fatigue in dyspneic ALS patients and whether fatigue is promoted by dyspnea. We further evaluated the correlation of fatigue with respiratory function tests.MethodsAbout 101 dyspneic patients and 20 matched controls completed the ALS Functional Rating Scale—Extension and the Fatigue Severity Scale. Dyspneic patients additionally completed the Dyspnea-ALS Scale and the ALS Assessment Questionnaire and underwent respiratory function tests (forced vital capacity, sniff nasal inspiratory pressure, mean inspiratory and expiratory pressure with respective relaxation rates, and blood gases). Multiple regression and correlation analyses were conducted.ResultsDyspneic patients had significantly higher fatigue scores than nondyspneic patients, and their fatigue significantly affected quality of life. Dyspnea alone explained up to 24
KW  - Amyotrophic Lateral Sclerosis: complications
KW  - Amyotrophic Lateral Sclerosis: diagnosis
KW  - Amyotrophic Lateral Sclerosis: therapy
KW  - Dyspnea: diagnosis
KW  - Dyspnea: etiology
KW  - Dyspnea: therapy
KW  - Fatigue: diagnosis
KW  - Fatigue: etiology
KW  - Fatigue: therapy
KW  - Humans
KW  - Quality of Life
KW  - Respiratory Insufficiency
LB  - PUB:(DE-HGF)16
C6  - pmid:32145336
DO  - DOI:10.1016/j.jpainsymman.2020.02.021
UR  - https://pub.dzne.de/record/153435
ER  -