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000153448 1001_ $$00000-0003-3229-1677$$aDörner, Marc$$b0$$eCorresponding author
000153448 245__ $$aPeripheral Nerve Imaging Aids in the Diagnosis of Immune-Mediated Neuropathies—A Case Series
000153448 260__ $$aBasel$$bMDPI$$c2020
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000153448 520__ $$aBackground: Diagnosis of immune-mediated neuropathies and their differentiation from amyotrophic lateral sclerosis (ALS) can be challenging, especially at early disease stages. Accurate diagnosis is, however, important due to the different prognosis and available treatment options. We present one patient with a left-sided dorsal flexor paresis and initial suspicion of ALS and another with multifocal sensory deficits. In both, peripheral nerve imaging was the key for diagnosis. Methods: We performed high-resolution nerve ultrasound (HRUS) and 7T or 3T magnetic resonance neurography (MRN). Results: In both patients, HRUS revealed mild to severe, segmental or inhomogeneous, nerve enlargement at multiple sites, as well as an area increase of isolated fascicles. MRN depicted T2 hyperintense nerves with additional contrast-enhancement. Discussion: Peripheral nerve imaging was compatible with the respective diagnosis of an immune-mediated neuropathy, i.e., multifocal motor neuropathy (MMN) in patient 1 and multifocal acquired demyelinating sensory and motor neuropathy (MADSAM) in patient 2. Peripheral nerve imaging, especially HRUS, should play an important role in the diagnostic work-up for immune-mediated neuropathies and their differentiation from ALS.
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000153448 7001_ $$0P:(DE-2719)9000986$$aSchreiber, Frank$$b1$$udzne
000153448 7001_ $$aStephanik, Heike$$b2
000153448 7001_ $$00000-0001-8570-4960$$aTempelmann, Claus$$b3
000153448 7001_ $$aWinter, Natalie$$b4
000153448 7001_ $$aStahl, Jan-Hendrik$$b5
000153448 7001_ $$aWittlinger, Julia$$b6
000153448 7001_ $$aWillikens, Sophia$$b7
000153448 7001_ $$aKramer, Magdalena$$b8
000153448 7001_ $$0P:(DE-2719)2260426$$aHeinze, Hans-Jochen$$b9$$udzne
000153448 7001_ $$0P:(DE-2719)2000035$$aVielhaber, Stefan$$b10$$udzne
000153448 7001_ $$aSchelle, Thomas$$b11
000153448 7001_ $$aGrimm, Alexander$$b12
000153448 7001_ $$0P:(DE-2719)2812631$$aSchreiber, Stefanie$$b13$$eLast author$$udzne
000153448 770__ $$aThe Diagnostic Value of Nerve and Muscle Ultrasound in Neuromuscular Disorders
000153448 773__ $$0PERI:(DE-600)2662336-5$$a10.3390/diagnostics10080535$$gVol. 10, no. 8, p. 535 -$$n8$$p535$$tDiagnostics$$v10$$x2075-4418$$y2020
000153448 8564_ $$uhttps://www.mdpi.com/2075-4418/10/8/535
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