TY  - JOUR
AU  - Dörner, Marc
AU  - Schreiber, Frank
AU  - Stephanik, Heike
AU  - Tempelmann, Claus
AU  - Winter, Natalie
AU  - Stahl, Jan-Hendrik
AU  - Wittlinger, Julia
AU  - Willikens, Sophia
AU  - Kramer, Magdalena
AU  - Heinze, Hans-Jochen
AU  - Vielhaber, Stefan
AU  - Schelle, Thomas
AU  - Grimm, Alexander
AU  - Schreiber, Stefanie
TI  - Peripheral Nerve Imaging Aids in the Diagnosis of Immune-Mediated Neuropathies—A Case Series
JO  - Diagnostics
VL  - 10
IS  - 8
SN  - 2075-4418
CY  - Basel
PB  - MDPI
M1  - DZNE-2020-01445
SP  - 535
PY  - 2020
AB  - Background: Diagnosis of immune-mediated neuropathies and their differentiation from amyotrophic lateral sclerosis (ALS) can be challenging, especially at early disease stages. Accurate diagnosis is, however, important due to the different prognosis and available treatment options. We present one patient with a left-sided dorsal flexor paresis and initial suspicion of ALS and another with multifocal sensory deficits. In both, peripheral nerve imaging was the key for diagnosis. Methods: We performed high-resolution nerve ultrasound (HRUS) and 7T or 3T magnetic resonance neurography (MRN). Results: In both patients, HRUS revealed mild to severe, segmental or inhomogeneous, nerve enlargement at multiple sites, as well as an area increase of isolated fascicles. MRN depicted T2 hyperintense nerves with additional contrast-enhancement. Discussion: Peripheral nerve imaging was compatible with the respective diagnosis of an immune-mediated neuropathy, i.e., multifocal motor neuropathy (MMN) in patient 1 and multifocal acquired demyelinating sensory and motor neuropathy (MADSAM) in patient 2. Peripheral nerve imaging, especially HRUS, should play an important role in the diagnostic work-up for immune-mediated neuropathies and their differentiation from ALS.
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC7459443
C6  - pmid:32751486
DO  - DOI:10.3390/diagnostics10080535
UR  - https://pub.dzne.de/record/153448
ER  -