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@ARTICLE{Drner:153448,
      author       = {Dörner, Marc and Schreiber, Frank and Stephanik, Heike and
                      Tempelmann, Claus and Winter, Natalie and Stahl, Jan-Hendrik
                      and Wittlinger, Julia and Willikens, Sophia and Kramer,
                      Magdalena and Heinze, Hans-Jochen and Vielhaber, Stefan and
                      Schelle, Thomas and Grimm, Alexander and Schreiber,
                      Stefanie},
      title        = {{P}eripheral {N}erve {I}maging {A}ids in the {D}iagnosis of
                      {I}mmune-{M}ediated {N}europathies—{A} {C}ase {S}eries},
      journal      = {Diagnostics},
      volume       = {10},
      number       = {8},
      issn         = {2075-4418},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2020-01445},
      pages        = {535},
      year         = {2020},
      abstract     = {Background: Diagnosis of immune-mediated neuropathies and
                      their differentiation from amyotrophic lateral sclerosis
                      (ALS) can be challenging, especially at early disease
                      stages. Accurate diagnosis is, however, important due to the
                      different prognosis and available treatment options. We
                      present one patient with a left-sided dorsal flexor paresis
                      and initial suspicion of ALS and another with multifocal
                      sensory deficits. In both, peripheral nerve imaging was the
                      key for diagnosis. Methods: We performed high-resolution
                      nerve ultrasound (HRUS) and 7T or 3T magnetic resonance
                      neurography (MRN). Results: In both patients, HRUS revealed
                      mild to severe, segmental or inhomogeneous, nerve
                      enlargement at multiple sites, as well as an area increase
                      of isolated fascicles. MRN depicted T2 hyperintense nerves
                      with additional contrast-enhancement. Discussion: Peripheral
                      nerve imaging was compatible with the respective diagnosis
                      of an immune-mediated neuropathy, i.e., multifocal motor
                      neuropathy (MMN) in patient 1 and multifocal acquired
                      demyelinating sensory and motor neuropathy (MADSAM) in
                      patient 2. Peripheral nerve imaging, especially HRUS, should
                      play an important role in the diagnostic work-up for
                      immune-mediated neuropathies and their differentiation from
                      ALS.},
      cin          = {U Clinical Researchers - Magdeburg / AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)7000000 / I:(DE-2719)5000006},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC7459443},
      pubmed       = {pmid:32751486},
      doi          = {10.3390/diagnostics10080535},
      url          = {https://pub.dzne.de/record/153448},
}