%0 Journal Article
%A Grasby, Katrina L.
%A Jahanshad, Neda
%A Neuroimaging, Mary Stevens
%A Painter, Jodie N.
%A Colodro-Conde, Lucía
%A Bralten, Janita
%A Hibar, Derrek P.
%A Neuroimaging, Mary Stevens
%A Lind, Penelope A.
%A Pizzagalli, Fabrizio
%A Neuroimaging, Mary Stevens
%A Ching, Christopher R. K.
%A Neuroimaging, Mary Stevens
%A McMahon, Mary Agnes B.
%A Neuroimaging, Mary Stevens
%A Shatokhina, Natalia
%A Neuroimaging, Mary Stevens
%A Zsembik, Leo C. P.
%A Thomopoulos, Sophia I.
%A Neuroimaging, Mary Stevens
%A Zhu, Alyssa H.
%A Neuroimaging, Mary Stevens
%A Strike, Lachlan T.
%A Agartz, Ingrid
%A Alhusaini, Saud
%A Almeida, Marcio A. A.
%A Diabetes, South Texas
%A Alnæs, Dag
%A Amlien, Inge K.
%A Andersson, Micael
%A Ard, Tyler
%A Neuroimaging, Mary Stevens
%A Armstrong, Nicola J.
%A Ashley-Koch, Allison
%A Atkins, Joshua R.
%A Bernard, Manon
%A Brouwer, Rachel M.
%A Buimer, Elizabeth E. L.
%A Bülow, Robin
%A Bürger, Christian
%A Cannon, Dara M.
%A Chakravarty, Mallar
%A Biological
%A Chen, Qiang
%A Cheung, Joshua W.
%A Neuroimaging, Mary Stevens
%A Couvy-Duchesne, Baptiste
%A Dale, Anders M.
%A Dalvie, Shareefa
%A de Araujo, Tânia K.
%A de Zubicaray, Greig I.
%A de Zwarte, Sonja M. C.
%A den Braber, Anouk
%A Doan, Nhat Trung
%A Dohm, Katharina
%A Ehrlich, Stefan
%A Medicine, Social
%A Engelbrecht, Hannah-Ruth
%A Erk, Susanne
%A Psychiatry, Brain Research Department of
%A Berlin, Psychotherapy Campus Charité Mitte Charité- Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu
%A Fan, Chun Chieh
%A Fedko, Iryna O.
%A Foley, Sonya F.
%A Ford, Judith M.
%A Fukunaga, Masaki
%A Garrett, Melanie E.
%A Ge, Tian
%A Giddaluru, Sudheer
%A Goldman, Aaron L.
%A Green, Melissa J.
%A Groenewold, Nynke A.
%A Grotegerd, Dominik
%A Gurholt, Tiril P.
%A Gutman, Boris A.
%A Neuroimaging, Mary Stevens
%A Hansell, Narelle K.
%A Harris, Mathew A.
%A Harrison, Marc B.
%A Neuroimaging, Mary Stevens
%A Haswell, Courtney C.
%A Hauser, Michael
%A Herms, Stefan
%A Heslenfeld, Dirk J.
%A Ho, New Fei
%A Hoehn, David
%A Hoffmann, Per
%A Holleran, Laurena
%A Hoogman, Martine
%A Hottenga, Jouke-Jan
%A Ikeda, Masashi
%A Janowitz, Deborah
%A Jansen, Iris E.
%A Jia, Tianye
%A Jockwitz, Christiane
%A Kanai, Ryota
%A Karama, Sherif
%A Kasperaviciute, Dalia
%A Kaufmann, Tobias
%A Kelly, Sinead
%A Kikuchi, Masataka
%A Klein, Marieke
%A Knapp, Michael
%A Knodt, Annchen R.
%A Krämer, Bernd
%A Psychiatry, Psychiatry Department of
%A Lam, Max
%A Lancaster, Thomas M.
%A Lee, Phil H.
%A Lett, Tristram A.
%A Psychiatry, Brain Research Department of
%A Berlin, Psychotherapy Campus Charité Mitte Charité- Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu
%A Lewis, Lindsay B.
%A Lopes-Cendes, Iscia
%A Luciano, Michelle
%A Macciardi, Fabio
%A Marquand, Andre F.
%A Mathias, Samuel R.
%A Melzer, Tracy R.
%A Milaneschi, Yuri
%A Universiteit, Amsterdam Neuroscience Amsterdam UMC/Vrije
%A Mirza-Schreiber, Nazanin
%A Moreira, Jose C. V.
%A Mühleisen, Thomas W.
%A Müller-Myhsok, Bertram
%A Najt, Pablo
%A Nakahara, Soichiro
%A Nho, Kwangsik
%A Olde Loohuis, Loes M.
%A Orfanos, Dimitri Papadopoulos
%A Pearson, John F.
%A Pitcher, Toni L.
%A Pütz, Benno
%A Quidé, Yann
%A Ragothaman, Anjanibhargavi
%A Neuroimaging, Mary Stevens
%A Rashid, Faisal M.
%A Neuroimaging, Mary Stevens
%A Reay, William R.
%A Redlich, Ronny
%A Reinbold, Céline S.
%A Repple, Jonathan
%A Richard, Geneviève
%A Riedel, Brandalyn C.
%A Neuroimaging, Mary Stevens
%A Risacher, Shannon L.
%A Rocha, Cristiane S.
%A Mota, Nina Roth
%A Salminen, Lauren
%A Neuroimaging, Mary Stevens
%A Saremi, Arvin
%A Neuroimaging, Mary Stevens
%A Saykin, Andrew J.
%A Schlag, Fenja
%A Schmaal, Lianne
%A Schofield, Peter R.
%A Secolin, Rodrigo
%A Shapland, Chin Yang
%A Shen, Li
%A Shin, Jean
%A Shumskaya, Elena
%A Sønderby, Ida E.
%A Sprooten, Emma
%A Tansey, Katherine E.
%A Teumer, Alexander
%A Thalamuthu, Anbupalam
%A Tordesillas-Gutiérrez, Diana
%A Turner, Jessica A.
%A Uhlmann, Anne
%A Vallerga, Costanza Ludovica
%A van der Meer, Dennis
%A Hospital, Addiction Oslo University
%A Medicine, Neuroscience Faculty of Health
%A van Donkelaar, Marjolein M. J.
%A van Eijk, Liza
%A van Erp, Theo G. M.
%A van Haren, Neeltje E. M.
%A van Rooij, Daan
%A van Tol, Marie-José
%A Veldink, Jan H.
%A Verhoef, Ellen
%A Walton, Esther
%A Wang, Mingyuan
%A Wang, Yunpeng
%A Wardlaw, Joanna M.
%A Wen, Wei
%A Westlye, Lars T.
%A Whelan, Christopher D.
%A Neuroimaging, Mary Stevens
%A Witt, Stephanie H.
%A Wittfeld, Katharina
%A Wolf, Christiane
%A Wolfers, Thomas
%A Wu, Jing Qin
%A Yasuda, Clarissa L.
%A Zaremba, Dario
%A Zhang, Zuo
%A Zwiers, Marcel P.
%A Artiges, Eric
%A Assareh, Amelia A.
%A Ayesa-Arriola, Rosa
%A Belger, Aysenil
%A Brandt, Christine L.
%A Brown, Gregory G.
%A Cichon, Sven
%A Curran, Joanne E.
%A Diabetes, South Texas
%A Davies, Gareth E.
%A Degenhardt, Franziska
%A Dennis, Michelle F.
%A Dietsche, Bruno
%A Djurovic, Srdjan
%A Doherty, Colin P.
%A Espiritu, Ryan
%A Garijo, Daniel
%A Gil, Yolanda
%A Gowland, Penny A.
%A Green, Robert C.
%A Häusler, Alexander N.
%A Heindel, Walter
%A Ho, Beng-Choon
%A Hoffmann, Wolfgang
%A Holsboer, Florian
%A Homuth, Georg
%A Hosten, Norbert
%A Jack, Clifford R.
%A Jang, MiHyun
%A Jansen, Andreas
%A Kimbrel, Nathan A.
%A Kolskår, Knut
%A Koops, Sanne
%A Krug, Axel
%A Lim, Kelvin O.
%A Luykx, Jurjen J.
%A Mathalon, Daniel H.
%A Mather, Karen A.
%A Mattay, Venkata S.
%A Matthews, Sarah
%A Mayoral Van Son, Jaqueline
%A McEwen, Sarah C.
%A Melle, Ingrid
%A Morris, Derek W.
%A Mueller, Bryon A.
%A Nauck, Matthias
%A Nordvik, Jan E.
%A Nöthen, Markus M.
%A O’Leary, Daniel S.
%A Opel, Nils
%A Martinot, Marie-Laure Paillère
%A Pike, G. Bruce
%A Preda, Adrian
%A Quinlan, Erin B.
%A Rasser, Paul E.
%A Ratnakar, Varun
%A Reppermund, Simone
%A Steen, Vidar M.
%A Tooney, Paul A.
%A Torres, Fábio R.
%A Veltman, Dick J.
%A Voyvodic, James T.
%A Whelan, Robert
%A White, Tonya
%A Yamamori, Hidenaga
%A Adams, Hieab H. H.
%A Bis, Joshua C.
%A Debette, Stephanie
%A Decarli, Charles
%A Fornage, Myriam
%A Gudnason, Vilmundur
%A Hofer, Edith
%A Ikram, M. Arfan
%A Launer, Lenore
%A Longstreth, W. T.
%A Lopez, Oscar L.
%A Mazoyer, Bernard
%A Mosley, Thomas H.
%A Roshchupkin, Gennady V.
%A Satizabal, Claudia L.
%A Schmidt, Reinhold
%A Seshadri, Sudha
%A Yang, Qiong
%A Alvim, Marina K. M.
%A Ames, David
%A Anderson, Tim J.
%A Andreassen, Ole A
%A Arias-Vasquez, Alejandro
%A Bastin, Mark E.
%A Baune, Bernhard T.
%A Beckham, Jean C.
%A Blangero, John
%A Diabetes, South Texas
%A Boomsma, Dorret I.
%A Brodaty, Henry
%A Brunner, Han G.
%A Oncology, School for
%A Buckner, Randy L.
%A Buitelaar, Jan K.
%A Bustillo, Juan R.
%A Cahn, Wiepke
%A Cairns, Murray J.
%A Calhoun, Vince
%A Carr, Vaughan J.
%A Caseras, Xavier
%A Caspers, Svenja
%A Cavalleri, Gianpiero L.
%A Cendes, Fernando
%A Corvin, Aiden
%A Crespo-Facorro, Benedicto
%A Dalrymple-Alford, John C.
%A Dannlowski, Udo
%A de Geus, Eco J. C.
%A Deary, Ian J.
%A Delanty, Norman
%A Depondt, Chantal
%A Desrivières, Sylvane
%A Donohoe, Gary
%A Espeseth, Thomas
%A Fernández, Guillén
%A Fisher, Simon E.
%A Flor, Herta
%A Forstner, Andreas J.
%A Francks, Clyde
%A Franke, Barbara
%A Glahn, David C.
%A Gollub, Randy L.
%A Grabe, Hans J.
%A Gruber, Oliver
%A Håberg, Asta K.
%A Hariri, Ahmad R.
%A Hartman, Catharina A.
%A Hashimoto, Ryota
%A Heinz, Andreas
%A Henskens, Frans A.
%A Hillegers, Manon H. J.
%A Hoekstra, Pieter J.
%A Holmes, Avram J.
%A Hong, L. Elliot
%A Hopkins, William D.
%A Hulshoff Pol, Hilleke E.
%A Jernigan, Terry L.
%A Jönsson, Erik G.
%A Kahn, René S.
%A Kennedy, Martin A.
%A Kircher, Tilo T. J.
%A Kochunov, Peter
%A Kwok, John B. J.
%A Brain, Epigenetics
%A Le Hellard, Stephanie
%A Loughland, Carmel M.
%A Martin, Nicholas G.
%A Martinot, Jean-Luc
%A McDonald, Colm
%A McMahon, Katie L.
%A Meyer-Lindenberg, Andreas
%A Michie, Patricia T.
%A Morey, Rajendra A.
%A Mowry, Bryan
%A Nyberg, Lars
%A Oosterlaan, Jaap
%A Ophoff, Roel A.
%A Pantelis, Christos
%A Paus, Tomas
%A Pausova, Zdenka
%A Penninx, Brenda W. J. H.
%A Polderman, Tinca J. C.
%A Posthuma, Danielle
%A Rietschel, Marcella
%A Roffman, Joshua L.
%A Rowland, Laura M.
%A Sachdev, Perminder S.
%A Sämann, Philipp G.
%A Schall, Ulrich
%A Schumann, Gunter
%A Scott, Rodney J.
%A Sim, Kang
%A Sisodiya, Sanjay M.
%A Smoller, Jordan W.
%A Sommer, Iris E.
%A St Pourcain, Beate
%A Stein, Dan J.
%A Toga, Arthur W.
%A Neuroimaging, Mary Stevens
%A Trollor, Julian N.
%A Van der Wee, Nic J. A.
%A van ’t Ent, Dennis
%A Völzke, Henry
%A Walter, Henrik
%A Psychiatry, Brain Research Department of
%A Berlin, Psychotherapy Campus Charité Mitte Charité- Universitätsmedizin Berlin corporate member of Freie Universität Berlin Humboldt-Universität zu
%A Weber, Bernd
%A Weinberger, Daniel R.
%A Wright, Margaret J.
%A Zhou, Juan
%A Stein, Jason L.
%A Thompson, Paul M.
%A Neuroimaging, Mary Stevens
%A Medland, Sarah E.
%T The genetic architecture of the human cerebral cortex
%J Science / Science now
%V 367
%N 6484
%@ 1095-9203
%C Washington, DC
%I Assoc.73085
%M DZNE-2021-00021
%P eaay6690 -
%D 2020
%X INTRODUCTIONThe cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure.RATIONALETo identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations.RESULTSWe identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness).Common genetic variants explained 34
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32193296
%R 10.1126/science.aay6690
%U https://pub.dzne.de/record/154039