% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Mueller:154194,
      author       = {Mueller, Sebastian and Stirnberg, Rüdiger and Akbey, Suzan
                      and Ehses, Philipp and Scheffler, Klaus and Stöcker, Tony
                      and Zaiss, Moritz},
      title        = {{W}hole brain snapshot {CEST} at 3{T} using 3{D}-{EPI}:
                      {A}iming for speed, volume, and homogeneity.},
      journal      = {Magnetic resonance in medicine},
      volume       = {84},
      number       = {5},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DZNE-2021-00056},
      pages        = {2469 - 2483},
      year         = {2020},
      abstract     = {CEST MRI enables imaging of distributions of
                      low-concentrated metabolites as well as proteins and
                      peptides and their alterations in diseases. CEST
                      examinations often suffer from low spatial resolution, long
                      acquisition times, and concomitant motion artifacts. This
                      work aims to maximize both resolution and volume coverage
                      with a 3D-EPI snapshot CEST approach at 3T, allowing for
                      fast and robust whole-brain CEST MRI.Resolution and temporal
                      SNR of 3D-EPI examinations with nonselective excitation were
                      optimized at a clinical 3T MR scanner in five healthy
                      subjects using a clinical head/neck coil. A CEST
                      presaturation module for low power relayed nuclear
                      Overhauser enhancement and amide proton transfer contrast
                      was applied as an example. The suggested postprocessing
                      included motion correction, dynamic B0 correction,
                      denoising, and B1 correction and was compared to an
                      established 3D-gradient echo-based sequence.CEST
                      examinations were performed at 1.8 mm nominal isotropic
                      resolution in 4.3 s per presaturation offset. In contrast
                      to slab-selective 3D or multislice approaches, the whole
                      brain was covered. Repeated examinations at three different
                      B1 values took 13 minutes for 58 presaturation offsets with
                      temporal SNR around 75. The resulting CEST effects revealed
                      significant gray and white matter contrast and were of
                      similar quality across the whole brain. Coefficient of
                      variation across three healthy subjects was below $9\%.The$
                      suggested protocol enables whole brain coverage at 1.8 mm
                      isotropic resolution and fast acquisition of 4.3 s per
                      presaturation offset. For the fitted CEST amplitudes, high
                      reproducibility was proven, increasing the opportunities of
                      quantitative CEST investigations at 3T significantly.},
      keywords     = {Brain: diagnostic imaging / Humans / Magnetic Resonance
                      Imaging / Protons / Reproducibility of Results / White
                      Matter / 3D CEST MRI (Other) / chemical exchange saturation
                      transfer MRI 3T (Other) / chemical exchange saturation
                      transfer MRI EPI (Other) / high resolution CEST MRI (Other)
                      / whole-brain CEST MRI (Other)},
      cin          = {AG Stöcker},
      ddc          = {610},
      cid          = {I:(DE-2719)1013026},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32385888},
      doi          = {10.1002/mrm.28298},
      url          = {https://pub.dzne.de/record/154194},
}