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000154201 037__ $$aDZNE-2021-00063
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000154201 1001_ $$00000-0003-1072-9375$$aSannemann, Lena$$b0$$eCorresponding author
000154201 245__ $$aNeuropsychiatric symptoms in at-risk groups for AD dementia and their association with worry and AD biomarkers—results from the DELCODE study
000154201 260__ $$aLondon$$bBioMed Central$$c2020
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000154201 520__ $$aBackgroundEarly identification of individuals at risk of dementia is mandatory to implement prevention strategies and design clinical trials that target early disease stages. Subjective cognitive decline (SCD) and neuropsychiatric symptoms (NPS) have been proposed as potential markers for early manifestation of Alzheimer’s disease (AD). We aimed to investigate the frequency of NPS in SCD, in other at-risk groups, in healthy controls (CO), and in AD patients, and to test the association of NPS with AD biomarkers, with a particular focus on cognitively unimpaired participants with or without SCD-related worries.MethodsWe analyzed data of n = 687 participants from the German DZNE Longitudinal Cognitive Impairment and Dementia (DELCODE) study, including the diagnostic groups SCD (n = 242), mild cognitive impairment (MCI, n = 115), AD (n = 77), CO (n = 209), and first-degree relatives of AD patients (REL, n = 44). The Neuropsychiatric Inventory Questionnaire (NPI-Q), Geriatric Depression Scale (GDS-15), and Geriatric Anxiety Inventory (GAI-SF) were used to assess NPS. We examined differences of NPS frequency between diagnostic groups. Logistic regression analyses were carried out to further investigate the relationship between NPS and cerebrospinal fluid (CSF) AD biomarkers, focusing on a subsample of cognitively unimpaired participants (SCD, REL, and CO), who were further differentiated based on reported worries.ResultsThe numbers of reported NPS, depression scores, and anxiety scores were significantly higher in subjects with SCD compared to CO. The quantity of reported NPS in subjects with SCD was lower compared to the MCI and AD group. In cognitively unimpaired subjects with worries, low Aß42 was associated with higher rates of reporting two or more NPS (OR 0.998, 95% CI 0.996–1.000, p < .05).ConclusionThese findings give insight into the prevalence of NPS in different diagnostic groups, including SCD and healthy controls. NPS based on informant report seem to be associated with underlying AD pathology in cognitively unimpaired participants who worry about cognitive decline.Trial registrationGerman Clinical Trials Register DRKS00007966. Registered 4 May 2015
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000154201 650_2 $$2MeSH$$aAged
000154201 650_2 $$2MeSH$$aAlzheimer Disease: epidemiology
000154201 650_2 $$2MeSH$$aAnxiety: epidemiology
000154201 650_2 $$2MeSH$$aBiomarkers
000154201 650_2 $$2MeSH$$aCognitive Dysfunction: epidemiology
000154201 650_2 $$2MeSH$$aHumans
000154201 650_2 $$2MeSH$$aLongitudinal Studies
000154201 650_2 $$2MeSH$$aNeuropsychological Tests
000154201 693__ $$0EXP:(DE-2719)DELCODE-20140101$$5EXP:(DE-2719)DELCODE-20140101$$eLongitudinal Cognitive Impairment and Dementia Study$$x0
000154201 7001_ $$0P:(DE-HGF)0$$aSchild, Ann-Katrin$$b1
000154201 7001_ $$0P:(DE-2719)2811720$$aAltenstein, Slawek$$b2
000154201 7001_ $$0P:(DE-2719)9000444$$aBartels, Claudia$$b3
000154201 7001_ $$0P:(DE-2719)2810593$$aBrosseron, Frederic$$b4
000154201 7001_ $$0P:(DE-2719)2811351$$aBürger, Katharina$$b5
000154201 7001_ $$aCosma, Nicoleta Carmen$$b6
000154201 7001_ $$0P:(DE-2719)2811326$$aFliessbach, Klaus$$b7
000154201 7001_ $$0P:(DE-HGF)0$$aFreiesleben, Silka Dawn$$b8
000154201 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b9
000154201 7001_ $$0P:(DE-2719)2000008$$aHeneka, Michael T.$$b10
000154201 7001_ $$aJanowitz, Daniel$$b11
000154201 7001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b12
000154201 7001_ $$0P:(DE-2719)9001475$$aKobeleva, Xenia$$b13$$udzne
000154201 7001_ $$0P:(DE-2719)2000055$$aLaske, Christoph$$b14
000154201 7001_ $$0P:(DE-2719)9000443$$aMetzger, Coraline D.$$b15
000154201 7001_ $$aMunk, Matthias H. J.$$b16
000154201 7001_ $$0P:(DE-2719)2812234$$aPerneczky, Robert$$b17
000154201 7001_ $$0P:(DE-HGF)0$$aPeters, Oliver$$b18
000154201 7001_ $$0P:(DE-2719)2810925$$aPolcher, Alexandra$$b19
000154201 7001_ $$0P:(DE-HGF)0$$aPriller, Josef$$b20
000154201 7001_ $$aRauchmann, Boris$$b21
000154201 7001_ $$0P:(DE-HGF)0$$aRösch, Christina$$b22
000154201 7001_ $$0P:(DE-2719)2812032$$aRudolph, Janna$$b23
000154201 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b24
000154201 7001_ $$0P:(DE-2719)2811324$$aSpottke, Annika$$b25
000154201 7001_ $$0P:(DE-HGF)0$$aSpruth, Eike Jakob$$b26
000154201 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan$$b27
000154201 7001_ $$0P:(DE-HGF)0$$aVukovich, Ruth$$b28
000154201 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b29
000154201 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b30
000154201 7001_ $$0P:(DE-2719)2810544$$aWolfsgruber, Steffen$$b31
000154201 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b32
000154201 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b33$$eLast author
000154201 773__ $$0PERI:(DE-600)2506521-X$$a10.1186/s13195-020-00701-7$$gVol. 12, no. 1, p. 131$$n1$$p131$$tAlzheimer's research & therapy$$v12$$x1758-9193$$y2020
000154201 8564_ $$uhttps://alzres.biomedcentral.com/articles/10.1186/s13195-020-00701-7
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