TY  - JOUR
AU  - Hoogman, Martine
AU  - van Rooij, Daan
AU  - Klein, Marieke
AU  - Boedhoe, Premika
AU  - Ilioska, Iva
AU  - Li, Ting
AU  - Patel, Yash
AU  - Postema, Merel C
AU  - Zhang-James, Yanli
AU  - Anagnostou, Evdokia
AU  - Arango, Celso
AU  - Auzias, Guillaume
AU  - Banaschewski, Tobias
AU  - Bau, Claiton H D
AU  - Behrmann, Marlene
AU  - Bellgrove, Mark A
AU  - Brandeis, Daniel
AU  - Brem, Silvia
AU  - Busatto, Geraldo F
AU  - Calderoni, Sara
AU  - Calvo, Rosa
AU  - Castellanos, Francisco X
AU  - Coghill, David
AU  - Conzelmann, Annette
AU  - Daly, Eileen
AU  - Deruelle, Christine
AU  - Dinstein, Ilan
AU  - Durston, Sarah
AU  - Ecker, Christine
AU  - Ehrlich, Stefan
AU  - Epstein, Jeffery N
AU  - Fair, Damien A
AU  - Fitzgerald, Jacqueline
AU  - Freitag, Christine M
AU  - Research, Psychotherapy Autism
AU  - Frodl, Thomas
AU  - Gallagher, Louise
AU  - Grevet, Eugenio H
AU  - Haavik, Jan
AU  - Hoekstra, Pieter J
AU  - Janssen, Joost
AU  - Karkashadze, Georgii
AU  - King, Joseph A
AU  - Konrad, Kerstin
AU  - Kuntsi, Jonna
AU  - Lazaro, Luisa
AU  - Lerch, Jason P
AU  - Lesch, Klaus-Peter
AU  - Louza, Mario R
AU  - Luna, Beatriz
AU  - Mattos, Paulo
AU  - McGrath, Jane
AU  - Muratori, Filippo
AU  - Murphy, Clodagh
AU  - Nigg, Joel T
AU  - Oberwelland-Weiss, Eileen
AU  - O'Gorman Tuura, Ruth L
AU  - O'Hearn, Kirsten
AU  - Oosterlaan, Jaap
AU  - Parellada, Mara
AU  - Pauli, Paul
AU  - Plessen, Kerstin J
AU  - Ramos-Quiroga, J Antoni
AU  - Reif, Andreas
AU  - Reneman, Liesbeth
AU  - Retico, Alessandra
AU  - Rosa, Pedro G P
AU  - Rubia, Katya
AU  - Shaw, Philip
AU  - Silk, Tim J
AU  - Tamm, Leanne
AU  - Vilarroya, Oscar
AU  - Walitza, Susanne
AU  - Jahanshad, Neda
AU  - Faraone, Stephen V
AU  - Neuroscience, of
AU  - Francks, Clyde
AU  - van den Heuvel, Odile A
AU  - Paus, Tomas
AU  - Thompson, Paul M
AU  - Buitelaar, Jan K
AU  - Franke, Barbara
TI  - Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.
JO  - Human brain mapping
VL  - 43
IS  - 1
SN  - 1097-0193
CY  - New York, NY
PB  - Wiley-Liss
M1  - DZNE-2021-00110
SP  - 37-55
PY  - 2022
AB  - Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
KW  - Attention Deficit Disorder with Hyperactivity: diagnostic imaging
KW  - Attention Deficit Disorder with Hyperactivity: pathology
KW  - Autism Spectrum Disorder: diagnostic imaging
KW  - Autism Spectrum Disorder: pathology
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Humans
KW  - Multicenter Studies as Topic
KW  - Neuroimaging
KW  - Neurosciences
KW  - ADHD (Other)
KW  - ASD (Other)
KW  - ENIGMA (Other)
KW  - cortex (Other)
KW  - neuroimaging (Other)
KW  - subcortical volumes (Other)
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC8675410
C6  - pmid:32420680
DO  - DOI:10.1002/hbm.25029
UR  - https://pub.dzne.de/record/154249
ER  -