%0 Journal Article
%A Rubinski, Anna
%A Franzmeier, Nicolai
%A Neitzel, Julia
%A Ewers, Michael
%T FDG-PET hypermetabolism is associated with higher tau-PET in mild cognitive impairment at low amyloid-PET levels.
%J Alzheimer's research & therapy
%V 12
%N 1
%@ 1758-9193
%C London
%I BioMed Central
%M DZNE-2021-00113
%P 133
%D 2020
%Z ISSN 1758-9193 not unique: **3 hits**.
%X FDG-PET hypermetabolism can be observed in mild cognitive impairment (MCI), but the link to primary pathologies of Alzheimer's diseases (AD) including amyloid and tau is unclear.Using voxel-based regression, we assessed local interactions between amyloid- and tau-PET on spatially matched FDG-PET in 72 MCI patients. Control groups included cerebrospinal fluid biomarker characterized cognitively normal (CN, n = 70) and AD dementia subjects (n = 95).In MCI, significant amyloid-PET by tau-PET interactions were found in frontal, lateral temporal, and posterior parietal regions, where higher local tau-PET was associated with higher spatially corresponding FDG-PET at low levels of local amyloid-PET. FDG-PET in brain regions with a significant local amyloid- by tau-PET interaction was higher compared to that in CN and AD dementia and associated with lower episodic memory.Higher tau-PET in the presence of low amyloid-PET is associated with abnormally increased glucose metabolism that is accompanied by episodic memory impairment.
%K Alzheimer Disease: diagnostic imaging
%K Amyloid
%K Amyloid beta-Peptides
%K Cognitive Dysfunction: diagnostic imaging
%K Fluorodeoxyglucose F18
%K Humans
%K Positron-Emission Tomography
%K tau Proteins
%K Amyloid-PET (Other)
%K FDG-PET (Other)
%K Hyperactivation (Other)
%K Hypermetabolism (Other)
%K Mild cognitive impairment (Other)
%K Tau-PET (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33076977
%2 pmc:PMC7574434
%R 10.1186/s13195-020-00702-6
%U https://pub.dzne.de/record/154259