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@ARTICLE{Rubinski:154259,
      author       = {Rubinski, Anna and Franzmeier, Nicolai and Neitzel, Julia
                      and Ewers, Michael},
      collaboration = {Initiative, Alzheimer’s Disease Neuroimaging},
      title        = {{FDG}-{PET} hypermetabolism is associated with higher
                      tau-{PET} in mild cognitive impairment at low amyloid-{PET}
                      levels.},
      journal      = {Alzheimer's research $\&$ therapy},
      volume       = {12},
      number       = {1},
      issn         = {1758-9193},
      address      = {London},
      publisher    = {BioMed Central},
      reportid     = {DZNE-2021-00113},
      pages        = {133},
      year         = {2020},
      note         = {ISSN 1758-9193 not unique: **3 hits**.},
      abstract     = {FDG-PET hypermetabolism can be observed in mild cognitive
                      impairment (MCI), but the link to primary pathologies of
                      Alzheimer's diseases (AD) including amyloid and tau is
                      unclear.Using voxel-based regression, we assessed local
                      interactions between amyloid- and tau-PET on spatially
                      matched FDG-PET in 72 MCI patients. Control groups included
                      cerebrospinal fluid biomarker characterized cognitively
                      normal (CN, n = 70) and AD dementia subjects (n = 95).In
                      MCI, significant amyloid-PET by tau-PET interactions were
                      found in frontal, lateral temporal, and posterior parietal
                      regions, where higher local tau-PET was associated with
                      higher spatially corresponding FDG-PET at low levels of
                      local amyloid-PET. FDG-PET in brain regions with a
                      significant local amyloid- by tau-PET interaction was higher
                      compared to that in CN and AD dementia and associated with
                      lower episodic memory.Higher tau-PET in the presence of low
                      amyloid-PET is associated with abnormally increased glucose
                      metabolism that is accompanied by episodic memory
                      impairment.},
      keywords     = {Alzheimer Disease: diagnostic imaging / Amyloid / Amyloid
                      beta-Peptides / Cognitive Dysfunction: diagnostic imaging /
                      Fluorodeoxyglucose F18 / Humans / Positron-Emission
                      Tomography / tau Proteins / Amyloid-PET (Other) / FDG-PET
                      (Other) / Hyperactivation (Other) / Hypermetabolism (Other)
                      / Mild cognitive impairment (Other) / Tau-PET (Other)},
      cin          = {AG Simons},
      ddc          = {610},
      cid          = {I:(DE-2719)1110008},
      pnm          = {341 - Molecular Signaling (POF3-341)},
      pid          = {G:(DE-HGF)POF3-341},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33076977},
      pmc          = {pmc:PMC7574434},
      doi          = {10.1186/s13195-020-00702-6},
      url          = {https://pub.dzne.de/record/154259},
}