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000154261 037__ $$aDZNE-2021-00115
000154261 041__ $$aEnglish
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000154261 1001_ $$00000-0003-0525-0714$$aMüller, Franziska E$$b0
000154261 245__ $$aSerotonin receptor 4 regulates hippocampal astrocyte morphology and function.
000154261 260__ $$aBognor Regis [u.a.]$$bWiley-Liss$$c2021
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000154261 520__ $$aAstrocytes are an important component of the multipartite synapse and crucial for proper neuronal network function. Although small GTPases of the Rho family are powerful regulators of cellular morphology, the signaling modules of Rho-mediated pathways in astrocytes remain enigmatic. Here we demonstrated that the serotonin receptor 4 (5-HT4 R) is expressed in hippocampal astrocytes, both in vitro and in vivo. Through fluorescence microscopy, we established that 5-HT4 R activation triggered RhoA activity via Gα13 -mediated signaling, which boosted filamentous actin assembly, leading to morphological changes in hippocampal astrocytes. We investigated the effects of these 5-HT4 R-mediated changes in mixed cultures and in acute slices, in which 5-HT4 R was expressed exclusively in astrocytes. In both systems, 5-HT4 R-RhoA signaling changed glutamatergic synaptic transmission: It increased the frequency of miniature excitatory postsynaptic currents (mEPSCs) in mixed cultures and reduced the paired-pulse-ratio (PPR) of field excitatory postsynaptic potentials (fEPSPs) in acute slices. Overall, our present findings demonstrate that astrocytic 5-HT4 R-Gα13 -RhoA signaling is a previously unrecognized molecular pathway involved in the functional regulation of excitatory synaptic circuits.
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000154261 650_7 $$2Other$$a5-ht Zeug
000154261 650_7 $$2Other$$aRhoA
000154261 650_7 $$2Other$$aactin
000154261 650_7 $$2Other$$aastrocytes
000154261 650_7 $$2Other$$aneuronal excitability
000154261 650_7 $$2Other$$aserotonin
000154261 650_2 $$2MeSH$$aAstrocytes
000154261 650_2 $$2MeSH$$aExcitatory Postsynaptic Potentials
000154261 650_2 $$2MeSH$$aHippocampus
000154261 650_2 $$2MeSH$$aReceptors, Serotonin: genetics
000154261 650_2 $$2MeSH$$aSerotonin
000154261 650_2 $$2MeSH$$aSynaptic Transmission
000154261 7001_ $$aSchade, Sophie K$$b1
000154261 7001_ $$aCherkas, Volodymyr$$b2
000154261 7001_ $$00000-0002-9648-6222$$aStopper, Laura$$b3
000154261 7001_ $$aBreithausen, Björn$$b4
000154261 7001_ $$aMinge, Daniel$$b5
000154261 7001_ $$0P:(DE-HGF)0$$aVarbanov, Hristo$$b6
000154261 7001_ $$aWahl-Schott, Christian$$b7
000154261 7001_ $$00000-0002-8226-1866$$aAntoniuk, Svitlana$$b8
000154261 7001_ $$aDomingos, Catia$$b9
000154261 7001_ $$00000-0002-4634-2765$$aCompan, Valérie$$b10
000154261 7001_ $$00000-0002-2324-2761$$aKirchhoff, Frank$$b11
000154261 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b12$$udzne
000154261 7001_ $$00000-0002-4570-5130$$aPonimaskin, Evgeni$$b13$$eCorresponding author
000154261 7001_ $$00000-0001-9858-5841$$aZeug, Andre$$b14$$eCorresponding author
000154261 773__ $$0PERI:(DE-600)1474828-9$$a10.1002/glia.23933$$gVol. 69, no. 4, p. 872 - 889$$n4$$p872 - 889$$tGlia$$v69$$x1098-1136$$y2021
000154261 8564_ $$uhttps://onlinelibrary.wiley.com/doi/10.1002/glia.23933
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