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@ARTICLE{Bakker:154282,
      author       = {Bakker, Mark K and van der Spek, Rick A A and van Rheenen,
                      Wouter and Morel, Sandrine and Bourcier, Romain and
                      Hostettler, Isabel C and Alg, Varinder S and van Eijk,
                      Kristel R and Koido, Masaru and Akiyama, Masato and Terao,
                      Chikashi and Matsuda, Koichi and Walters, Robin G and Lin,
                      Kuang and Li, Liming and Millwood, Iona Y and Chen,
                      Zhengming and Rouleau, Guy A and Zhou, Sirui and Rannikmäe,
                      Kristiina and Sudlow, Cathie L M and Houlden, Henry and van
                      den Berg, Leonard H and Dina, Christian and Naggara, Olivier
                      and Gentric, Jean-Christophe and Shotar, Eimad and Eugène,
                      François and Desal, Hubert and Winsvold, Bendik S and
                      Børte, Sigrid and Johnsen, Marianne Bakke and Brumpton, Ben
                      M and Sandvei, Marie Søfteland and Willer, Cristen J and
                      Hveem, Kristian and Zwart, John-Anker and Verschuren, W M
                      Monique and Friedrich, Christoph M and Hirsch, Sven and
                      Schilling, Sabine and Dauvillier, Jérôme and Martin,
                      Olivier and Genetics and Jones, Gregory T and Bown, Matthew
                      J and Ko, Nerissa U and Kim, Helen and Coleman, Jonathan R I
                      and Breen, Gerome and Zaroff, Jonathan G and Klijn,
                      Catharina J M and Malik, Rainer and Dichgans, Martin and
                      Sargurupremraj, Muralidharan and Tatlisumak, Turgut and
                      Amouyel, Philippe and Debette, Stéphanie and Rinkel,
                      Gabriel J E and Worrall, Bradford B and Pera, Joanna and
                      Slowik, Agnieszka and Gaál-Paavola, Emília I and Niemelä,
                      Mika and Jääskeläinen, Juha E and von Und Zu Fraunberg,
                      Mikael and Lindgren, Antti and Broderick, Joseph P and
                      Werring, David J and Woo, Daniel and Redon, Richard and
                      Bijlenga, Philippe and Kamatani, Yoichiro and Veldink, Jan H
                      and Ruigrok, Ynte M and Bian, Zheng and Chen, Junshi and
                      Chen, Yiping and Clarke, Robert and Collins, Rory and Guo,
                      Yu and Han, Xiao and Hill, Michael and Liu, Depei and Lv,
                      Jun and Millwood, Iona and Peto, Richard and Sansome, Sam
                      and Walters, Robin and Yang, Xiaoming and Yu, Canqing and
                      Bonner, Stephen and Walsh, Daniel and Bulters, Diederik and
                      Kitchen, Neil and Brown, Martin and Grieve, Joan and
                      Dichgans, Martin},
      collaboration = {Stroke, HUNT All-In and Group, China Kadoorie Biobank
                      Collaborative and Consortium, BioBank Japan Project and
                      Group, ICAN Study and Group, CADISP and Haemorrhage,
                      Observational Subarachnoid and Consortium, International
                      Stroke Genetics},
      title        = {{G}enome-wide association study of intracranial aneurysms
                      identifies 17 risk loci and genetic overlap with clinical
                      risk factors.},
      journal      = {Nature genetics},
      volume       = {52},
      number       = {12},
      issn         = {1546-1718},
      address      = {London},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2021-00136},
      pages        = {1303 - 1313},
      year         = {2020},
      note         = {ISSN 1546-1718 not unique: **3 hits**.},
      abstract     = {Rupture of an intracranial aneurysm leads to subarachnoid
                      hemorrhage, a severe type of stroke. To discover new risk
                      loci and the genetic architecture of intracranial aneurysms,
                      we performed a cross-ancestry, genome-wide association study
                      in 10,754 cases and 306,882 controls of European and East
                      Asian ancestry. We discovered 17 risk loci, 11 of which are
                      new. We reveal a polygenic architecture and explain over
                      half of the disease heritability. We show a high genetic
                      correlation between ruptured and unruptured intracranial
                      aneurysms. We also find a suggestive role for endothelial
                      cells by using gene mapping and heritability enrichment.
                      Drug-target enrichment shows pleiotropy between intracranial
                      aneurysms and antiepileptic and sex hormone drugs, providing
                      insights into intracranial aneurysm pathophysiology.
                      Finally, genetic risks for smoking and high blood pressure,
                      the two main clinical risk factors, play important roles in
                      intracranial aneurysm risk, and drive most of the genetic
                      correlation between intracranial aneurysms and other
                      cerebrovascular traits.},
      keywords     = {Asian People: genetics / Asian Continental Ancestry Group:
                      genetics / Blood Pressure: genetics / Case-Control Studies /
                      Endothelial Cells: pathology / European Continental Ancestry
                      Group: genetics / Genetic Predisposition to Disease:
                      genetics / Genome-Wide Association Study / Humans /
                      Hypertension: genetics / Hypertension: physiopathology /
                      Intracranial Aneurysm: genetics / Intracranial Aneurysm:
                      pathology / Polymorphism, Single Nucleotide: genetics / Risk
                      Factors / Smoking: adverse effects / Smoking: genetics /
                      Subarachnoid Hemorrhage: genetics / Subarachnoid Hemorrhage:
                      pathology / White People: genetics},
      cin          = {Clinical Research (Munich)},
      ddc          = {570},
      cid          = {I:(DE-2719)1111015},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33199917},
      pmc          = {pmc:PMC7116530},
      doi          = {10.1038/s41588-020-00725-7},
      url          = {https://pub.dzne.de/record/154282},
}