Home > Publications Database > Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. > print

001     154291
005     20230915094032.0
024 7 _ |a 10.1038/s41418-020-0584-2
|2 doi
024 7 _ |a pmid:32641776
|2 pmid
024 7 _ |a pmc:PMC7853040
|2 pmc
024 7 _ |a 1350-9047
|2 ISSN
024 7 _ |a 1476-5403
|2 ISSN
024 7 _ |a altmetric:85525463
|2 altmetric
037 _ _ |a DZNE-2021-00145
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Bertan, Fabio
|0 P:(DE-2719)2810664
|b 0
|e First author
|u dzne
245 _ _ |a Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability.
260 _ _ |a London
|c 2020
|b Macmillan
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1617105774_11425
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a ISSN 1476-5403 not unique: **3 hits**.
520 _ _ |a Dendritic spines are postsynaptic domains that shape structural and functional properties of neurons. Upon neuronal activity, Ca2+ transients trigger signaling cascades that determine the plastic remodeling of dendritic spines, which modulate learning and memory. Here, we study in mice the role of the intracellular Ca2+ channel Ryanodine Receptor 2 (RyR2) in synaptic plasticity and memory formation. We demonstrate that loss of RyR2 in pyramidal neurons of the hippocampus impairs maintenance and activity-evoked structural plasticity of dendritic spines during memory acquisition. Furthermore, post-developmental deletion of RyR2 causes loss of excitatory synapses, dendritic sparsification, overcompensatory excitability, network hyperactivity and disruption of spatially tuned place cells. Altogether, our data underpin RyR2 as a link between spine remodeling, circuitry dysfunction and memory acquisition, which closely resemble pathological mechanisms observed in neurodegenerative disorders.
536 _ _ |a 341 - Molecular Signaling (POF3-341)
|0 G:(DE-HGF)POF3-341
|c POF3-341
|f POF III
|x 0
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
|0 G:(DE-HGF)POF3-342
|c POF3-342
|f POF III
|x 1
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Dendritic Spines: physiology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Hippocampus: metabolism
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Mice, Knockout
|2 MeSH
650 _ 2 |a Neuronal Plasticity: physiology
|2 MeSH
650 _ 2 |a Pyramidal Cells: metabolism
|2 MeSH
650 _ 2 |a Ryanodine Receptor Calcium Release Channel: metabolism
|2 MeSH
650 _ 2 |a Synapses: physiology
|2 MeSH
700 1 _ |a Wischhof, Lena
|0 P:(DE-2719)2811527
|b 1
|u dzne
700 1 _ |a Sosulina, Liudmila
|0 P:(DE-2719)2810715
|b 2
|u dzne
700 1 _ |a Mittag, Manuel
|0 P:(DE-2719)2811044
|b 3
|u dzne
700 1 _ |a Dalügge, Dennis
|0 P:(DE-2719)2811426
|b 4
|u dzne
700 1 _ |a Fornarelli, Alessandra
|0 P:(DE-2719)2690858
|b 5
|u dzne
700 1 _ |a Gardoni, Fabrizio
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Marcello, Elena
|0 P:(DE-HGF)0
|b 7
700 1 _ |a Di Luca, Monica
|0 P:(DE-HGF)0
|b 8
700 1 _ |a Fuhrmann, Martin
|0 P:(DE-2719)2679991
|b 9
|u dzne
700 1 _ |a Remy, Stefan
|0 P:(DE-2719)2810375
|b 10
|u dzne
700 1 _ |a Bano, Daniele
|0 P:(DE-2719)2158358
|b 11
|e Corresponding author
|u dzne
700 1 _ |a Nicotera, Pierluigi
|0 P:(DE-2719)2010732
|b 12
|e Last author
|u dzne
773 _ _ |a 10.1038/s41418-020-0584-2
|g Vol. 27, no. 12, p. 3354 - 3373
|0 PERI:(DE-600)1496681-5
|n 12
|p 3354 - 3373
|t Cell death and differentiation
|v 27
|y 2020
|x 1476-5403
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/154291/files/41418_2020_Article_584.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/154291/files/41418_2020_Article_584.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:154291
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)2810664
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)2811527
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 2
|6 P:(DE-2719)2810715
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 3
|6 P:(DE-2719)2811044
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 4
|6 P:(DE-2719)2811426
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 5
|6 P:(DE-2719)2690858
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 9
|6 P:(DE-2719)2679991
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 10
|6 P:(DE-2719)2810375
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 11
|6 P:(DE-2719)2158358
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 12
|6 P:(DE-2719)2010732
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-341
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Molecular Signaling
|x 0
913 1 _ |a DE-HGF
|b Gesundheit
|l Erkrankungen des Nervensystems
|1 G:(DE-HGF)POF3-340
|0 G:(DE-HGF)POF3-342
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Disease Mechanisms and Model Systems
|x 1
913 2 _ |a DE-HGF
|b Programmungebundene Forschung
|l ohne Programm
|1 G:(DE-HGF)POF4-890
|0 G:(DE-HGF)POF4-899
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-800
|4 G:(DE-HGF)POF
|v ohne Topic
|x 0
914 1 _ |y 2020
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-01-26
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-26
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2022-11-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2022-11-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2022-11-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2022-11-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2022-11-30
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b CELL DEATH DIFFER : 2021
|d 2022-11-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2022-11-30
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2022-11-30
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2022-11-30
915 _ _ |a IF >= 10
|0 StatID:(DE-HGF)9910
|2 StatID
|b CELL DEATH DIFFER : 2021
|d 2022-11-30
920 1 _ |0 I:(DE-2719)1013003
|k AG Nicotera / Bano ; AG Bano
|l Aging and neurodegeneration
|x 0
920 1 _ |0 I:(DE-2719)1013006
|k AG Remy
|l Neuronal Networks
|x 1
920 1 _ |0 I:(DE-2719)1011004
|k AG Fuhrmann
|l Neuroimmunology and Imaging
|x 2
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1013003
980 _ _ |a I:(DE-2719)1013006
980 _ _ |a I:(DE-2719)1011004
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21