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000154305 0247_ $$2ISSN$$a2235-154X
000154305 037__ $$aDZNE-2021-00159
000154305 041__ $$aEnglish
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000154305 1001_ $$0P:(DE-HGF)0$$aHajek, André$$b0
000154305 245__ $$aWhich Factors Contribute to Frailty among the Oldest Old? Results of the Multicentre Prospective AgeCoDe and AgeQualiDe Study.
000154305 260__ $$aBasel [u.a.]$$bKarger$$c2020
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000154305 520__ $$aThere is a lack of studies investigating the link between time-varying factors associated with changes in frailty scores in very old age longitudinally. This is important because the level of frailty is associated with subsequent morbidity and mortality.To examine time-dependent predictors of frailty among the oldest old using a longitudinal approach.Longitudinal data were drawn from the multicentre prospective cohort study 'Study on Needs, health service use, costs and health-related quality of life in a large sample of oldest-old primary care patients (85+)' (AgeQualiDe), covering primary care patients aged 85 years and over. Three waves were used (from follow-up, FU, wave 7 to FU wave 9 [with 10 months between each wave]; 1,301 observations in the analytical sample). Frailty was assessed using the Canadian Study of Health and Aging (CSHA) Clinical Frailty Scale (CFS). As explanatory variables, we included sociodemographic factors (marital status and age), social isolation as well as health-related variables (depression, dementia, and chronic diseases) in a regression analysis.In total, 18.9% of the individuals were mildly frail, 12.4% of the individuals were moderately frail, and 0.4% of the individuals were severely frail at FU wave 7. Fixed effects regressions revealed that increases in frailty were associated with increases in age (β = 0.23, p < 0.001), and dementia (β = 0.84, p < 0.01), as well as increases in chronic conditions (β = 0.03, p = 0.058).The study findings particularly emphasize the importance of changes in age, probably chronic conditions as well as dementia for frailty. Future research is required to elucidate the underlying mechanisms. Furthermore, future longitudinal studies based on panel regression models are required to confirm our findings.
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000154305 650_7 $$2Other$$aChronic conditions
000154305 650_7 $$2Other$$aChronic illness
000154305 650_7 $$2Other$$aComorbidity
000154305 650_7 $$2Other$$aDementia
000154305 650_7 $$2Other$$aDepression
000154305 650_7 $$2Other$$aFrailty
000154305 650_7 $$2Other$$aLongitudinal study
000154305 650_7 $$2Other$$aOldest old
000154305 650_7 $$2Other$$aPhysical illness
000154305 650_2 $$2MeSH$$aActivities of Daily Living
000154305 650_2 $$2MeSH$$aAged, 80 and over
000154305 650_2 $$2MeSH$$aCanada: epidemiology
000154305 650_2 $$2MeSH$$aCohort Studies
000154305 650_2 $$2MeSH$$aFemale
000154305 650_2 $$2MeSH$$aFrail Elderly: statistics & numerical data
000154305 650_2 $$2MeSH$$aFrailty: epidemiology
000154305 650_2 $$2MeSH$$aHumans
000154305 650_2 $$2MeSH$$aLongitudinal Studies
000154305 650_2 $$2MeSH$$aMale
000154305 650_2 $$2MeSH$$aPrimary Health Care: statistics & numerical data
000154305 650_2 $$2MeSH$$aProspective Studies
000154305 650_2 $$2MeSH$$aQuality of Life
000154305 7001_ $$0P:(DE-HGF)0$$aBrettschneider, Christian$$b1
000154305 7001_ $$0P:(DE-HGF)0$$aRöhr, Susanne$$b2
000154305 7001_ $$0P:(DE-HGF)0$$aGühne, Uta$$b3
000154305 7001_ $$0P:(DE-HGF)0$$avan der Leeden, Carolin$$b4
000154305 7001_ $$0P:(DE-HGF)0$$aLühmann, Dagmar$$b5
000154305 7001_ $$0P:(DE-HGF)0$$aMamone, Silke$$b6
000154305 7001_ $$0P:(DE-HGF)0$$aWiese, Birgitt$$b7
000154305 7001_ $$0P:(DE-HGF)0$$aWeyerer, Siegfried$$b8
000154305 7001_ $$0P:(DE-HGF)0$$aWerle, Jochen$$b9
000154305 7001_ $$0P:(DE-HGF)0$$aFuchs, Angela$$b10
000154305 7001_ $$0P:(DE-HGF)0$$aPentzek, Michael$$b11
000154305 7001_ $$0P:(DE-HGF)0$$aWeeg, Dagmar$$b12
000154305 7001_ $$0P:(DE-HGF)0$$aMösch, Edelgard$$b13
000154305 7001_ $$0P:(DE-2719)9000848$$aHeser, Kathrin$$b14$$udzne
000154305 7001_ $$0P:(DE-2719)2000057$$aWagner, Michael$$b15$$udzne
000154305 7001_ $$0P:(DE-2719)2000015$$aMaier, Wolfgang$$b16$$udzne
000154305 7001_ $$0P:(DE-HGF)0$$aRiedel-Heller, Steffi G$$b17
000154305 7001_ $$0P:(DE-HGF)0$$aScherer, Martin$$b18
000154305 7001_ $$0P:(DE-HGF)0$$aKönig, Hans-Helmut$$b19
000154305 773__ $$0PERI:(DE-600)1482689-6$$a10.1159/000508723$$gVol. 66, no. 5, p. 460 - 466$$n5$$p460 - 466$$tGerontology$$v66$$x1423-0003$$y2020
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