% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Singh:154308,
      author       = {Singh, Manvendra and Bansal, Vikas and Feschotte, Cédric},
      title        = {{A} {S}ingle-{C}ell {RNA} {E}xpression {M}ap of {H}uman
                      {C}oronavirus {E}ntry {F}actors.},
      journal      = {Cell reports},
      volume       = {32},
      number       = {12},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-00162},
      pages        = {108175},
      year         = {2020},
      note         = {ISSN 2211-1247 not unique: **3 hits**.},
      abstract     = {To predict the tropism of human coronaviruses, we profile
                      28 SARS-CoV-2 and coronavirus-associated receptors and
                      factors (SCARFs) using single-cell transcriptomics across
                      various healthy human tissues. SCARFs include cellular
                      factors both facilitating and restricting viral entry.
                      Intestinal goblet cells, enterocytes, and kidney proximal
                      tubule cells appear highly permissive to SARS-CoV-2,
                      consistent with clinical data. Our analysis also predicts
                      non-canonical entry paths for lung and brain infections.
                      Spermatogonial cells and prostate endocrine cells also
                      appear to be permissive to SARS-CoV-2 infection, suggesting
                      male-specific vulnerabilities. Both pro- and anti-viral
                      factors are highly expressed within the nasal epithelium,
                      with potential age-dependent variation, predicting an
                      important battleground for coronavirus infection. Our
                      analysis also suggests that early embryonic and placental
                      development are at moderate risk of infection. Lastly, SCARF
                      expression appears broadly conserved across a subset of
                      primate organs examined. Our study establishes a resource
                      for investigations of coronavirus biology and pathology.},
      keywords     = {A549 Cells / Angiotensin-Converting Enzyme 2 / Animals /
                      Betacoronavirus: growth $\&$ development / COVID-19 / Cell
                      Line / Chlorocebus aethiops / Coronavirus Infections:
                      pathology / Enterocytes: metabolism / Gene Expression
                      Profiling / Goblet Cells: metabolism / HEK293 Cells / Humans
                      / Kidney Tubules, Proximal: cytology / Kidney Tubules,
                      Proximal: metabolism / Nasal Mucosa: metabolism / Nasal
                      Mucosa: virology / Pandemics / Peptidyl-Dipeptidase A:
                      genetics / Peptidyl-Dipeptidase A: metabolism / Pneumonia,
                      Viral: pathology / Receptors, Virus: genetics / SARS-CoV-2 /
                      Serine Endopeptidases: genetics / Serine Endopeptidases:
                      metabolism / Single-Cell Analysis / Vero Cells / Viral
                      Tropism: genetics / Virus Internalization / COVID-19 (Other)
                      / SARS-CoV-2 (Other) / coronaviruses (Other) / restriction
                      factors (Other) / scRNA-seq (Other) / viral receptors
                      (Other) / Receptors, Virus (NLM Chemicals) /
                      Peptidyl-Dipeptidase A (NLM Chemicals) / ACE2 protein, human
                      (NLM Chemicals) / Angiotensin-Converting Enzyme 2 (NLM
                      Chemicals) / Serine Endopeptidases (NLM Chemicals) / TMPRSS2
                      protein, human (NLM Chemicals)},
      cin          = {AG Bonn 1},
      ddc          = {610},
      cid          = {I:(DE-2719)1410003},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32946807},
      pmc          = {pmc:PMC7470764},
      doi          = {10.1016/j.celrep.2020.108175},
      url          = {https://pub.dzne.de/record/154308},
}