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000154309 0247_ $$2doi$$a10.1016/j.celrep.2020.108182
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000154309 037__ $$aDZNE-2021-00163
000154309 041__ $$aEnglish
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000154309 1001_ $$0P:(DE-HGF)0$$aHerde, Michel K$$b0
000154309 245__ $$aLocal Efficacy of Glutamate Uptake Decreases with Synapse Size.
000154309 260__ $$a[New York, NY]$$bElsevier$$c2020
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000154309 520__ $$aSynaptically released glutamate is largely cleared by glutamate transporters localized on perisynaptic astrocyte processes. Therefore, the substantial variability of astrocyte coverage of individual hippocampal synapses implies that the efficacy of local glutamate uptake and thus the spatial fidelity of synaptic transmission is synapse dependent. By visualization of sub-diffraction-limit perisynaptic astrocytic processes and adjacent postsynaptic spines, we show that, relative to their size, small spines display a stronger coverage by astroglial transporters than bigger neighboring spines. Similarly, glutamate transients evoked by synaptic stimulation are more sensitive to pharmacological inhibition of glutamate uptake at smaller spines, whose high-affinity N-methyl-D-aspartate receptors (NMDARs) are better shielded from remotely released glutamate. At small spines, glutamate-induced and NMDAR-dependent Ca2+ entry is also more strongly increased by uptake inhibition. These findings indicate that spine size inversely correlates with the efficacy of local glutamate uptake and thereby likely determines the probability of synaptic crosstalk.
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000154309 650_7 $$2Other$$aastrocyte morphology
000154309 650_7 $$2Other$$aastrocytes
000154309 650_7 $$2Other$$aexpansion microscopy
000154309 650_7 $$2Other$$aglutamate uptake
000154309 650_7 $$2Other$$ahippocampus
000154309 650_7 $$2Other$$amultiphoton imaging
000154309 650_7 $$2Other$$aspine morphology
000154309 650_2 $$2MeSH$$aAmino Acid Transport System X-AG: metabolism
000154309 650_2 $$2MeSH$$aAnimals
000154309 650_2 $$2MeSH$$aAstrocytes: metabolism
000154309 650_2 $$2MeSH$$aCalcium: metabolism
000154309 650_2 $$2MeSH$$aCell Size
000154309 650_2 $$2MeSH$$aDendritic Spines: metabolism
000154309 650_2 $$2MeSH$$aFemale
000154309 650_2 $$2MeSH$$aGlutamic Acid: metabolism
000154309 650_2 $$2MeSH$$aMale
000154309 650_2 $$2MeSH$$aMice
000154309 650_2 $$2MeSH$$aReceptors, N-Methyl-D-Aspartate: metabolism
000154309 650_2 $$2MeSH$$aSynapses: metabolism
000154309 7001_ $$0P:(DE-HGF)0$$aBohmbach, Kirsten$$b1
000154309 7001_ $$0P:(DE-HGF)0$$aDomingos, Cátia$$b2
000154309 7001_ $$0P:(DE-HGF)0$$aVana, Natascha$$b3
000154309 7001_ $$0P:(DE-HGF)0$$aKomorowska-Müller, Joanna A$$b4
000154309 7001_ $$0P:(DE-HGF)0$$aPasslick, Stefan$$b5
000154309 7001_ $$0P:(DE-HGF)0$$aSchwarz, Inna$$b6
000154309 7001_ $$0P:(DE-HGF)0$$aJackson, Colin J$$b7
000154309 7001_ $$0P:(DE-HGF)0$$aDietrich, Dirk$$b8
000154309 7001_ $$0P:(DE-HGF)0$$aSchwarz, Martin K$$b9
000154309 7001_ $$0P:(DE-2719)2811625$$aHenneberger, Christian$$b10$$eLast author$$udzne
000154309 773__ $$0PERI:(DE-600)2649101-1$$a10.1016/j.celrep.2020.108182$$gVol. 32, no. 12, p. 108182 -$$n12$$p108182$$tCell reports$$v32$$x2211-1247$$y2020
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