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@ARTICLE{Herde:154309,
      author       = {Herde, Michel K and Bohmbach, Kirsten and Domingos, Cátia
                      and Vana, Natascha and Komorowska-Müller, Joanna A and
                      Passlick, Stefan and Schwarz, Inna and Jackson, Colin J and
                      Dietrich, Dirk and Schwarz, Martin K and Henneberger,
                      Christian},
      title        = {{L}ocal {E}fficacy of {G}lutamate {U}ptake {D}ecreases with
                      {S}ynapse {S}ize.},
      journal      = {Cell reports},
      volume       = {32},
      number       = {12},
      issn         = {2211-1247},
      address      = {[New York, NY]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2021-00163},
      pages        = {108182},
      year         = {2020},
      note         = {ISSN 2211-1247 not unique: **3 hits**.},
      abstract     = {Synaptically released glutamate is largely cleared by
                      glutamate transporters localized on perisynaptic astrocyte
                      processes. Therefore, the substantial variability of
                      astrocyte coverage of individual hippocampal synapses
                      implies that the efficacy of local glutamate uptake and thus
                      the spatial fidelity of synaptic transmission is synapse
                      dependent. By visualization of sub-diffraction-limit
                      perisynaptic astrocytic processes and adjacent postsynaptic
                      spines, we show that, relative to their size, small spines
                      display a stronger coverage by astroglial transporters than
                      bigger neighboring spines. Similarly, glutamate transients
                      evoked by synaptic stimulation are more sensitive to
                      pharmacological inhibition of glutamate uptake at smaller
                      spines, whose high-affinity N-methyl-D-aspartate receptors
                      (NMDARs) are better shielded from remotely released
                      glutamate. At small spines, glutamate-induced and
                      NMDAR-dependent Ca2+ entry is also more strongly increased
                      by uptake inhibition. These findings indicate that spine
                      size inversely correlates with the efficacy of local
                      glutamate uptake and thereby likely determines the
                      probability of synaptic crosstalk.},
      keywords     = {Amino Acid Transport System X-AG: metabolism / Animals /
                      Astrocytes: metabolism / Calcium: metabolism / Cell Size /
                      Dendritic Spines: metabolism / Female / Glutamic Acid:
                      metabolism / Male / Mice / Receptors, N-Methyl-D-Aspartate:
                      metabolism / Synapses: metabolism / astrocyte morphology
                      (Other) / astrocytes (Other) / expansion microscopy (Other)
                      / glutamate uptake (Other) / hippocampus (Other) /
                      multiphoton imaging (Other) / spine morphology (Other)},
      cin          = {U Preclinical Researchers - Bonn},
      ddc          = {610},
      cid          = {I:(DE-2719)7000005},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32966786},
      doi          = {10.1016/j.celrep.2020.108182},
      url          = {https://pub.dzne.de/record/154309},
}